フルテキストURL ijo_49_2_499.pdf
著者 Yamada, Chiaki| Aikawa, Tomonao| Okuno, Emi| Miyagawa, Kazuaki| Amano, Katsuhiko| Takahata, Sosuke| Kimata, Masaaki| Okura, Masaya| Iida, Seiji| Kogo, Mikihiko|
抄録 Odontogenic tumors and cysts, arising in the jawbones, grow by resorption and destruction of the jawbones. However, mechanisms underlying bone resorption by odontogenic tumors/cysts remain unclear. Odontogenic tumors/cysts comprise odontogenic epithelial cells and stromal fibroblasts, which originate from the developing tooth germ. It has been demonstrated that odontogenic epithelial cells of the developing tooth germ induce osteoclastogenesis to prevent the tooth germ from invading the developing bone to maintain its structure in developing bones. Thus, we hypothesized that odontogenic epithelial cells of odontogenic tumors/cysts induce osteoclast formation, which plays potential roles in tumor/cyst outgrowth into the jawbone. The purpose of this study was to examine osteoclastogenesis by cytokines, focusing on transforming growth factor-β (TGF-β), produced by odontogenic epithelial cells. We observed two pathways for receptor activator of NF-κB ligand (RANKL) induction by keratocystic odontogenic tumor fluid: the cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) pathway through interleukin-1α (IL-1α) signaling and non-COX-2/PGE2 pathway through TGF-β receptor signaling. TGF-β1 and IL-1α produced by odontogenic tumors/cysts induced osteoclastogenesis directly in the osteoclast precursor cells and indirectly via increased RANKL induction in the stroma.
発行日 2016-05-31
出版物タイトル International Journal of Oncology
49巻
2号
出版者 Spandidos
開始ページ 499
終了ページ 508
ISSN 1019-6439
NCID AA10992511
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン publisher
PubMed ID 27279422
DOI 10.3892/ijo.2016.3548
Web of Sience KeyUT 000378263600007
関連URL isVersionOf https://doi.org/10.3892/ijo.2016.3548