JaLCDOI 10.18926/AMO/32634
フルテキストURL fulltext.pdf
著者 Motoi, Makoto| Wahid, Syariffudin| Horie, Yasushi| Akagi, Tadaatsu|
抄録 <p>In the present study, 14 cases of Kimura's disease were clinicopathologically studied. The disease occurred at ages ranging from 5 to 75 years. The average age was 37.8 years. Sexes were about equally affected. The most common sites were the subcutis of head and neck, and parotid gland. Simultaneous involvement of lymph nodes occurred in 5 cases. Laboratory findings revealed eosinophilia in almost all the patients, but serum IgE levels were not elevated in 2 patients. Lesions were surgically removed and the clinical course thereafter was favorable for all but one case. Histologically, lesions were characterized by lymphoid follicles, granulation tissue with infiltration by many eosinophils, lymphocytes, plasma cells, mast cells and histiocytes, proliferation of blood vessels and fibrosis. Immunohistochemically, IgE reacted strongly in germinal centers, showing a reticular pattern. IgG-, IgA- and lysozyme-positive cells were scattered mainly in interfollicular granulomatous areas. Pathogenesis of this disease is briefly discussed.</p>
キーワード Kimura's disease clinicopathology immunohistochemistry
Amo Type Article
発行日 1992-12
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 449
終了ページ 455
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 1485539
Web of Sience KeyUT A1992KE49600007