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ID 34166
フルテキストURL
著者
Ikeda, Masashi Fujita Health University, Aichi
Iwata, Nakao Okayama University
Suzuki, Tatsuyo Fujita Health University
Kitajima, Tsuyoshi Fujita Health University, Aichi
Yamanouchi, Yoshio Fujita Health University
Kinoshita, Yoko Fujita Health University
Sekine, Yoshimoto Okayama University
Iyo, Masaomi Okayama University
Harano, Mutsuo Okayama University
Komiyama, Tokutaro Okayama University
Yamada, Mitsuhiko Okayama University
Sora, Ichiro Okayama University
Ujike, Hiroshi Okayama University
Inada, Toshiya Okayama University
Ozaki, Norio Okayama University
抄録

Recent evidence suggests that the AKT1-GSK3Β signalling cascade partially mediates dopaminedependentbehaviours. In relation to the pathophysiology of schizophrenia or methamphetamine (Meth)use disorder, AKT1 is a good candidate gene for such conditions. For schizophrenia, positive associationsof SNPs and AKT1 haplotypes were reported in US and Japanese samples. To evaluate the association between AKT1 and Meth-use disorder, we conducted a case-control study of Japanese samples (182 patients and 437 controls). A positive association between a SNP and haplotypes was found, and the ‘signal’ SNP was the same SNP found to be associated with US schizophrenia, but not with Japanese schizophrenia. Our results indicate that AKT1 may play a possible role in the development of Meth-use disorder. Further investigation of these associations, together with evidence from previous animal studies, may open the way to elucidation of the pathophysiology of this condition.

キーワード
Dopamine-dependent behaviours
linkage disequilibrium
substance-related disorders.
備考
Digital Object Identifier:10.1017/S1461145705005481
Published with permission from the copyright holder. This is the institute's copy, as published in The International Journal of Neuropsychopharmacology, Feb. 2006, Volume 9, Issue 1, Pages 77-81.
Publisher URL:http://dx.doi.org/10.1017/S1461145705005481
Copyright © 2005 Collegium Internationale Neuropsychopharmacologicum. All rights reserved.
発行日
2006-2
出版物タイトル
The International Journal of Neuropsychopharmacology
9巻
1号
開始ページ
77
終了ページ
81
資料タイプ
学術雑誌論文
言語
English
査読
有り
DOI
Submission Path
pharmacology_general/1