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ID 32984
フルテキストURL
著者
Hashimoto, Tasuku Department of Psychiatry, Chiba University Graduate School of Medicine
Hashimoto, Kenji Department of Psychiatry, Chiba University Graduate School of Medicine
Matsuzaka, Daisuke Department of Psychiatry, Chiba University Graduate School of Medicine
Shimizu, Eiji Department of Psychiatry, Chiba University Graduate School of Medicine
Sekine, Yoshimoto Department of Psychiatry and Neurology, Hamamatsu University School of Medicine
Yoshiya, Inada Department of Psychiatry, Nagoya University Graduate School of Medicine
Iwata, Nakao Department of Psychiatry, Fujita Health University School of Medicine
Harano, Mutsuo Department of Neuropsychiatry, Kurume University School of Medicine
Komiyama, Tokutaro National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry (NCNP)
Yamada, Mitsuhiko National Institute of Mental Health, NCNP
Sora, Ichiro Division of Psychobiology, Tohoku University Graduate School of Medicine
Ujike, Hiroshi Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry
Iyo, Masaomi Department of Psychiatry, Chiba University Graduate School of Medicine
抄録
Several lines of evidence suggest that oxidative stress plays a role in the mechanisms of action of methamphetamine (MAP) in the human brain. Given the role of glutathione S-transferases (GSTs) in the protection against oxidative stress, genes encoding the GSTs have been considered as candidates for association studies of MAP abuse. This study was undertaken to investigate the role of the functional polymorphism of GSTP1 gene exon 5 (Ile105Val) in the pathogenesis of MAP abuse. Genotyping for GSTP1 gene polymorphism exon 5 (Ile105Val) in 189 MAP abusers and 199 normal controls was performed by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). Association between GSTP1 gene polymorphism and clinical features (prognosis of psychosis (transient-type and prolonged-type), spontaneous relapse (positive and negative), and poly-substance abuse) of MAP abusers was evaluated. Significant differences in the frequency of both alleles (P = 0.026, odds ratio: 1.70, 95% confidence intervals (CI) 1.06-2.72) and genotypes (P = 0.029) between MAP abusers and controls were detected. In particular, a significant difference in both genotype frequency (P = 0.013) and allele frequency (P = 0.014, odds ratio: 1.84, 95% CI 1.13-2.97) between MAP abusers with psychosis (transient-type and prolonged-type) and controls was detected. Our findings suggest that the polymorphism (Ile 105Val) on exon 5 of the GSTP1 gene may contribute to a vulnerability to psychosis associated with MAP abuse in Japanese population.
キーワード
methamphetamine
psychosis
drug abuse
genetic factor; polymorphism
備考
Digital Object Identifer: 10.1002/ajmg.b.30164
Published with permission from the copyright holder. This is the author's copy, as published in American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, May 2005, Volume 135B, Issue 1, Pages 5-9.
Publisher URL:http://dx.doi.org/10.1002/ajmg.b.30164
Direct access to Thomson Web of Science record
Copyright © 2005 Wiley-Liss, Inc. All rights reserved.
発行日
2005-05-05
出版物タイトル
American Journal of Medical Genetics Part B, Neuropsychiatric Genetics
135B巻
1号
出版者
Wiley-Liss, Inc.
開始ページ
5
終了ページ
9
ISSN
1552-4841
NCID
AA11815089
資料タイプ
学術雑誌論文
言語
English
著作権者
Wiley-Liss, Inc.
論文のバージョン
author
査読
有り
DOI
PubMed ID
Web of Sience KeyUT
Submission Path
biology_general/26