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ID 32980
フルテキストURL
著者
Itoh, Kanako Department of Psychiatry, Chiba University Graduate School of Medicine
Hashimoto, Kenji Department of Psychiatry, Chiba University Graduate School of Medicine
Shimizu, Eiji Department of Psychiatry, Chiba University Graduate School of Medicine
Sekine, Yoshimoto Department of Psychiatry and Neurology, Hamamatsu University School of Medicine
Ozaki, Norio Department of Psychiatry and Psychobiology, Nagoya University Graduate School of Medicine
Inada, Toshiya Department of Psychiatry and Psychobiology, Nagoya University Graduate School of Medicine
Harano, Mutsuo Department of Neuropsychiatry, Kurume University School of Medicine
Iwata, Nakao Department of Psychiatry, Fujita Health University School of Medicine
Komiyama, Tokutaro National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry
Yamada, Mitsuhiko Karasuyama Hospital, Showa University School of Medicine
Sora, Ichiro Division of Psychobiology, Tohoku University Graduate School of Medicine
Nakata, Kenji Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry
Ujike, Hiroshi Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry
Iyo, Masaomi Department of Psychiatry, Chiba University Graduate School of Medicine
抄録
Several lines of evidence suggest that genetic factors might contribute to drug abuse vulnerability. Recent genomic scans for association demonstrated that the brain-derived neurotrophic factor (BDNF) gene was associated with drug abuse vulnerability. In this study, we analyzed association of two BDNF gene single nucleotide polymorphisms (SNPs), 132C>T (C270T named formerly) in the noncoding region of exon V and 196G >A (val66met) in the coding region of exon XIIIA, with methamphetamine (MAP) abuse in Japan. No significant differences were found in the frequency of the genotype or allele in these two SNPs between MAP abusers and controls (132C>T in exon V: genotype, p = 0.586, allele, p = 0.594; 196G>A (val66met) in exon XIIIA: genotype, p = 0.889, allele, p = 0.713). Furthermore, there was no difference between clinical parameters (e.g. prognosis psychosis, spontaneous relapse, or poly-substance abuse) and the two SNPs of BDNF gene. These results suggest that the two SNPs (132C>T in exon V and 196G>A (val66met) in exon XIIIA) of the BDNF gene may not be associated with Japanese MAP abusers.
キーワード
brain-derived neurotrophic factor
polymorphism
drug abuse
methamphetamine
備考
Digital Object Identifer:10.1002/ajmg.b.30097
Published with permission from the copyright holder. This is the author's copy, as published in American Journal of Medical Genetics Part B, Neuropsychiatric Genetics, Jan 2005, Volume 132B, Issue 1, Pages 70-73.
Publisher URL:http://dx.doi.org/10.1002/ajmg.b.30097
Direct access to Thomson Web of Science record
Copyright © 2004 Wiley-Liss, Inc. All rights reserved.
発行日
2005-01-05
出版物タイトル
American Journal of Medical Genetics Part B, Neuropsychiatric Genetics
132B巻
1号
出版者
Wiley-Liss, Inc.
開始ページ
70
終了ページ
73
ISSN
1552-4841
NCID
AA11815089
資料タイプ
学術雑誌論文
言語
English
著作権者
Wiley-Liss, Inc.
論文のバージョン
author
査読
有り
DOI
PubMed ID
Web of Sience KeyUT
Submission Path
biology_general/32