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ID 32937
フルテキストURL
著者
Ikeda, Masashi Department of Psychiatry, Fujita Health University School of Medicine
Iwata, Nakao Japanese Genetics Initiative for Drug Abuse (JGIDA), Okayama University Graduate School of Medicine and Dentistry
Suzuki, Tatsuyo Department of Psychiatry, Fujita Health University School of Medicine
Kitajima, Tsuyoshi Department of Psychiatry, Fujita Health University School of Medicine
Yamanouchi, Yoshio Department of Psychiatry, Fujita Health University School of Medicine
Kinoshiya, Yoko Department of Psychiatry, Fujita Health University School of Medicine
Sekine, Yoshimoto Japanese Genetics Initiative for Drug Abuse (JGIDA), Okayama University Graduate School of Medicine and Dentistry
Iyo, Masaomi Japanese Genetics Initiative for Drug Abuse (JGIDA), Okayama University Graduate School of Medicine and Dentistry
Harano, Mutsuo Japanese Genetics Initiative for Drug Abuse (JGIDA), Okayama University Graduate School of Medicine and Dentistry
Komiyama, Tokutaro Japanese Genetics Initiative for Drug Abuse (JGIDA), Okayama University Graduate School of Medicine and Dentistry
Yamada, Mitsuhiko Japanese Genetics Initiative for Drug Abuse (JGIDA), Okayama University Graduate School of Medicine and Dentistry
Sora, Ichiro Japanese Genetics Initiative for Drug Abuse (JGIDA), Okayama University Graduate School of Medicine and Dentistry
Ujike, Hiroshi Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry
Inada, Toshiya Japanese Genetics Initiative for Drug Abuse (JGIDA), Okayama University Graduate School of Medicine and Dentistry
Ozaki, Norio Japanese Genetics Initiative for Drug Abuse (JGIDA), Okayama University Graduate School of Medicine and Dentistry
抄録

Recent evidence suggests that the AKT1-GSK3b signalling cascade partially mediates dopaminedependent behaviours. In relation to the pathophysiology of schizophrenia or methamphetamine (Meth) use disorder, AKT1 is a good candidate gene for such conditions. For schizophrenia, positive associations of SNPs and AKT1 haplotypes were reported in US and Japanese samples. To evaluate the association between AKT1 and Meth-use disorder, we conducted a case-control study of Japanese samples (182 patients and 437 controls). A positive association between a SNP and haplotypes was found, and the ‘signal’ SNP was the same SNP found to be associated with US schizophrenia, but not with Japanese schizophrenia. Our results indicate that AKT1 may play a possible role in the development of Meth-use disorder. Further investigation of these associations, together with evidence from previous animal studies, may open the way to elucidation of the pathophysiology of this condition.

キーワード
Dopamine-dependent behaviours
linkage disequilibrium
substance-related disorders
備考
Published with permission from the copyright holder.>br /> This is published in International Journal of Neuropsychopharmacology , 2006 Feb, volume 9, Issue.1, pp 77-81.
Publisher URL: http://dx.doi.org/10.1017/S1461145705005481
Direct access to Thomson Web of Science record
Copyright © 2006 Cambridge University Press All rights reserved.
発行日
2008-09-04
出版物タイトル
International Journal of Neuropsychopharmacology
9巻
1号
資料タイプ
学術雑誌論文
言語
English
査読
有り
DOI
Web of Sience KeyUT
Submission Path
neuroscience/4