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ID 31582
JaLCDOI
フルテキストURL
著者
Kawamoto, Hirofumi First Department of Internal Medicine, Okayama University Medical School
Sakaguchi, Kohsaku First Department of Internal Medicine, Okayama University Medical School
Takaki, Akinobu First Department of Internal Medicine, Okayama University Medical School Kaken ID
Ogawa, Shin First Department of Internal Medicine, Okayama University Medical School
Tsuji, Takao First Department of Internal Medicine, Okayama University Medical School
抄録
We investigated autoimmunity, as assessed by hypergammaglobulinemia and the presence of autoantibodies including anti-nuclear antibodies (ANA) and anti-liver membrane antibodies (LMA), in 149 patients with chronic hepatitis C, 55 patients with chronic hepatitis B and 11 patients with autoimmune hepatitis. There was no significant difference in the incidence of these autoantibodies between chronic hepatitis C and chronic hepatitis B. Nine patients with chronic hepatitis C satisfied the serological criteria of autoimmune hepatitis (ANA positive and gammaglobulin or serum IgG greater than 2500 mg/dl), but none of the patients with chronic hepatitis B met the criteria. This suggests that autoimmunity is greater in chronic hepatitis C than in chronic hepatitis B. Of the 9 patients with chronic hepatitis C, all 4 patients tested for human leukocyte antigen (HLA) phenotype had HLA-DR4, which is known to be associated with autoimmune hepatitis in Japanese patients. We believe that hepatitis C virus (HCV) infection enhances the initiation and perpetuation of autoimmunity in susceptible individuals.
キーワード
chronic hepatitis C
autoimmune hepatitis
anti-nuclear antibodyies
anti-liver membrane antibodies HLA
Amo Type
Article
発行日
1993-10
出版物タイトル
Acta Medica Okayama
47巻
5号
出版者
Okayama University Medical School
開始ページ
305
終了ページ
310
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
Copyright© Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/2332