JaLCDOI 10.18926/AMO/30941
フルテキストURL fulltext.pdf
著者 Ota, Kei| Mizuno, Toshihide| Tatsumi, Eisuke| Katagiri, Nobumasa| Taenaka, Yoshiyuki| Ishizuka, Takanobu| Ogata, Yoshitaka| Ujike, Yoshihito|
抄録 <p>Percutaneous cardiopulmonary support (PCPS) has been applied for cardiopulmonary arrest (CPA). We have developed a novel method of cardiopulmonary resuscitation using PCPS combined with liposome-encapsulated hemoglobin (TRM645) to improve oxygen delivery to vital organs. Ventricular fibrillation was electrically induced to an adult goat for 10 min. Next, PCPS (30 ml/kg/min, V/Q: 1) was performed for 20 min. Then, external defibrillation was attempted and observed for 120 min. The TRM group (n5) was filled with 300 mL of TRM645 for the PCPS circuit. The control group (n5) was filled with the same volume of saline. The delivery of oxygen (DO2) and oxygen consumption (VO2) decreased markedly by PCPS after CPA, compared to the preoperative values. DO2 was kept at a constant level during PCPS in both groups, but VO2 slowly decreased at 5, 10, and 15 min of PCPS in the control groups, demonstrating that systemic oxygen metabolism decreased with time. In contrast, the decreases in VO2 were small in the TRM group at 5, 10, and 15 min of PCPS, demonstrating that TRM645 continuously maintained systemic oxygen consumption even at a low flow rate. AST and LDH in the TRM group were lower than the control. There were significant differences at 120 min after the restoration of spontaneous circulation (p&#60;0.05).</p>
キーワード percutaneous cardiopulmonary support liposome-encapsulated hemoglobin cardiopulmonary resuscitation
Amo Type Original Article
発行日 2008-08
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 235
終了ページ 239
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 18766206
Web of Science KeyUT 000258680900003