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ID 14468
Eprint ID
14468
フルテキストURL
Thumnail 103_129.pdf 9.12 MB
タイトル(別表記)
Neurophysiological study of deep brain stimulation for the treatment of deafferentation pain Part 1. Influence of neurotransmitters upon deafferentation hyperactivity in cats -Participation of GABA in the descending inhibitory system-
著者
富田 享 岡山大学医学部脳神経外科学教室
抄録
Deafferentation hyperactivity (DH) was provoked in the neurons of the subnucleus caudalis of the spinal trigeminal nucleus and the lateral reticular formation in cats by Gasserian ganglionectomy, and was used as a model of peripheral deafferentation pain. The influence of neurochemical substances upon DH was investigated. Neurotransmitters and their antagonists were applied topically around the soma of hyperactive neruons by the microiontophoretic technique, using a 7-barreled glass micropipette. Then the participation of inhibitory amino acids in the descending inhibitory systems, which were activated by deep brain stimulation (DBS), was investigated. Discharges of hyperactive neurons (n=75) were recorded extracellularly and analyzed using a spike density histogram. DH was suppressed by topically injected GABA and glycine, but not by met-enkephalin. The suppressive effects of GABA and glycine were almost completely antagonized by bicuculline and strychnine, respectively. Stimulation of the internal capsule or VPM suppressed DH, and this suppression was not affected by microiontophoretically injected bicuculline or strychnine. Intravenous injection of picrotoxin reduced the suppression, but intravenous strychnine did not. GABA may play an important role as an inhibitory neurotransmitter in the descending inhibitory systems activated by DBS.
キーワード
deafferentation pain
deafferentation hyperactivity
GABA
glycine
descending inhibitory system
備考
原著
発行日
1991
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
103巻
1-2号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
129
終了ページ
146
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/103/1-2/103_1-2_129/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma