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ID 51592
フルテキストURL
著者
Iwanaga, Suketaka Department of Public Health, Faculty of Medicine, Kyoto University
Sakano, Noriko Department of Hygiene, Faculty of Medicine, Kagawa University
Taketa, Kazuhisa Geriatric Health Service Facility, Niwanosato Home
Takahashi, Noriko Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Wang, Da-Hong Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Takahashi, Hidekazu Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kubo, Masayuki Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Miyatake, Nobuyuki Department of Hygiene, Faculty of Medicine, Kagawa University
Ogino, Keiki Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
抄録
Objective Metabolic syndrome (MS) is closely associated to life-style and is characterized by central obesity causing severe diseases such as diabetes mellitus (DM) or atherosclerosis. This study investigates the role of oxidative stress and inflammation in MS. Subjects Total of 685 workers stratified by gender (293 men and 392 women) with a mean age of 41.2 ± 10.4 in different offices in a city in Japan. Methods Fasting blood and urine tests for MS, oxidative and/or inflammatory biomarker analysis and blood pressure (BP) measurement were performed. MS was defined on the basis of the Japanese criterion. Results Serum ferritin and urinary hydrogen peroxide (H2O2) levels were significantly higher in subjects with MS than those without. Ferritin was positively correlated with 8-hydroxy-2′-deoxyguanosine (8-OHdG) in all subjects and it was negatively correlated with 8-isoprostane and H2O2 in men. In addition, there was a significant positive correlation between ferritin and homeostasis model assessment (HOMA-R) in men. By using multiple regression analysis, ferritin was closely correlated with HOMA-R, γ-GT, 8-OHdG, smoking value and amount of alcohol ingestion in men, and it was correlated with 8-OHdG, γ-GT, HOMA-R in women under 50 years old. Conclusions Ferritin is a useful marker of MS including insulin resistance, reflecting the importance of oxidative stress as a cause of MS, especially in men.
キーワード
Oxidative stress
Ferritin
8-Hydroxy-2′-deoxyguanosine (8-OHdG)
Hydrogen peroxide (H2O2)
Metabolic syndrome
発行日
2013-02-01
出版物タイトル
Obesity Research & Clinical Practice
資料タイプ
学術雑誌論文
オフィシャル URL
http://dx.doi.org/10.1016/j.orcp.2013.01.003
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/51461
言語
English
著作権者
© 2013 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
論文のバージョン
author
査読
有り
DOI