このエントリーをはてなブックマークに追加
ID 30962
JaLCDOI
フルテキストURL
著者
Otani, Satoru Division of Cardiovascular Surgery, National Hospital Organization, Iwakuni Clinical Center
Kuinose, Masahiko Division of Cardiovascular Surgery, Sakakibara Hospital
Murakami, Takashi Department of Nursing Science, Kochi Women’s University
Saito, Shinya Division of Surgery, National Hospital Organization, Fukuyama Medical Center
Iwagaki, Hiromi Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Tanaka, Noriaki Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Tanemoto, Kazuo Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Kawasaki Medical School
抄録

Activation of inflammatory response during cardiopulmonary bypass (CPB) may lead to considerable post-operative mortality. Recently, pentoxifylline (PTX), a methylxanthine derivative, has been reported to be effective in inhibiting proinflammatory cytokine production. This study aimed to determine whether or not PTX prevented CPB-induced systemic inflammatory response syndrome (SIRS) in patients undergoing cardiovascular surgery. Thirty adult patients were randomly separated into 2 experimental groups and 1 control group of 10 patients each. The experimental group received peroral PTX administration (Group 1: 600 mg/day, Group 2: 900 mg/day), while the control group did not. In Group 1 and Group 2, PTX administration was started on preoperative day 5 and continued for 5 days. Serum levels of PTX and IL-6 were measured just before and at 4 h after CPB using HPLC and ELISA, respectively. Respiratory index (RI) before and at 4 h after CPB was calculated, and serum levels of C-reactive protein (CRP) and fibrinogen on postoperative day 1 were also determined. There were no significant differences in age, body weight, sex, surgical procedures, CPB time, haemodynamics or risk factors among the 3 groups. Serum IL-6 level and RI index after CPB in Group 2 were significantly decreased compared with those in Group 1 and the control group. These results, therefore, suggested that preoperative daily administration of 900 mg/day PTX contributed to the attenuation of CPB-induced SIRS and had a beneficial effect on the postoperative course after cardiovascular surgery.

キーワード
pentoxifylline
CPB
IL-6
SIRS
respiratory index
Amo Type
Original Article
発行日
2008-04
出版物タイトル
Acta Medica Okayama
62巻
2号
出版者
Okayama University Medical School
開始ページ
69
終了ページ
74
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT