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ID 13994
Eprint ID
13994
フルテキストURL
Thumnail 105_903.pdf 825 KB
タイトル(別表記)
Leukemic cell destruction kinetics in bone marrow
著者
竹内 誠 岡山大学医学部第二内科学教室
抄録
An equation was developed to describe the kinetics of leukemic cell destruction in bone marrow during induction chemotherapy for acute nonlymphocytic leukemia (logZ=K(1)t(4)+K(2)t(3)+K(3)t(2)+K(4), where Z=leukemic cell number, t=time, and K=a constant). The leukemic cell destruction curve was biphasic ; phase Ⅰ was the period from the initiation of a decrease in cells to the maximum velocity of the decrease, and phase Ⅱ was the subsequent period to the cessation of decrease. The following parameters were established : duration and acceleration of decrease in phases Ⅰ and Ⅱ, maximum velocity of decrease, duration of reduction, and residual volume of leukemic cells. 1. Patients who achieved CR showed a longer duration of phases Ⅰ and Ⅱ, a lower acceleration of the decrease in phase Ⅱ, and smaller residual leukemic cell volume than patients who did not achieve CR. there were no significant differences of parameters related to FAB classification, type of induction therapy, or the age of the patients. 2. This equation could be adapted to explain erythroblast kinetics during induction chemotherapy. There were no significant differences of the parameters with respect to the effect of induction therapy and patient age. 3. Patients with high acceleration of the decrease in phase Ⅱ had a short duration of CR and survival. The leukemic cell destruction curve was thought to be useful not only for evaluation of the effect of induction therapy, but also for establishment of post-remission chemotherapy.
キーワード
acute leukemia
leukemic cell destruction curve
leukemic cell destruction kinetics
remission induction chemotherapy
備考
原著
発行日
1993-12-31
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
105巻
11-12号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
903
終了ページ
918
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/105/11-12/105_11-12_903/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma