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ID 31041
JaLCDOI
フルテキストURL
著者
Tanaka, Kotaro Okayama University
Sakagami, Kenichi Okayama University
Orita, Kunzo Okayama University
抄録

It is now well recognized that pre-transplant donor-specific blood transfusion (DST) has a beneficial effect on the survival of allografts. To determine the optimal interval between DST and transplantation, and to analyze the mechanisms of this effect, the survival of cardiac allografts to rats which received a single DST was examined. The cardiac allograft survival was found to be prolonged when the DST was performed 1 to 6 weeks before grafting. In addition, recipient rat sera collected 1 to 6 weeks after a single DST showed significant inhibition of a mixed lymphocyte reaction (MLR). This MLR inhibition correlated with prolongation of survival of histoincompatible rat cardiac allografts. It thus appears that a single DST given from 1 to 6 weeks before transplantation has a beneficial effect on allograft survival and that MLR inhibition may be essential for inducing the effect of transfusion on organ transplantation.

キーワード
donor-specific blood transfusion
cardiac allograftingm
mixed lymphocyte reaction
Amo Type
Article
発行日
1988-02
出版物タイトル
Acta Medica Okayama
42巻
1号
出版者
Okayama University Medical School
開始ページ
31
終了ページ
36
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT