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ID 32041
JaLCDOI
フルテキストURL
Thumnail fulltext.pdf 1020 KB
著者
Yokoyama, Hisamitsu Okayama University
Yumane, Yukio Okayama University
Takahara, Jiro Okayama University
Yoshinouchi, Takeo Okayama University
Ofuji, Tadashi Okayama University
抄録

An unusual case of orbital tumor with high renin content and severe hypertension is described. The patient was a 15-year-old girl with juvenile hypertension (200-140 mmHg) associated with right exophthalmos and hypokalemia. The patient showed extremely high levels of plasma renin activity and plasma aldosterone concentration. No difference was present in plasma renin activity from either side of the renal veins. Preoperatively, hypertension responded to treatment with spironolactone. The tumor could not be completely removed because of intracranial metastasis and infiltration, and the hyperreninemia and secondary hyperaldosteronism persisted. The renin content in the orbital tissue was 1,403-2,225 ng/angiotensin I generated/h/g wet weight of tissue. The postmortem histopathologic diagnosis was orbital hemangiopericytoma. This is the first case of extrarenal (ectopic) renin-secreting (or -producing) hemangiopericytoma of the orbital origin. Furthermore this case is worthy of note in the point of view of the presence of the extrarenal renin-angiotensin system, particularly in the brain.

キーワード
renin producing tumor
hemangiopericytoma
juvenile hypertension
hypokalemia
orbital tumor
Amo Type
Brief Note
発行日
1979-08
出版物タイトル
Acta Medica Okayama
33巻
4号
出版者
Okayama University Medical School
開始ページ
315
終了ページ
322
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
NAID