JaLCDOI 10.18926/AMO/32783
フルテキストURL fulltext.pdf
著者 Ueki, Ayako| Tada, Hiroshi| Seno, Satimaru|
抄録 <p>Antigenicity of clozapine was studied in rabbits, comparing with that of chlorpromazine as control. The results indicate that chlorpromazine produces antibody in rabbit as revealed by passive hemagglutination test, giving the titer of 1 : 2, 000 or higher in all the five cases observed, though specific precipitin lines has not been obtained and PCA test proves to be negative. Clozapine failed to produce anti.clozapine antibody giving negative passive hemagglutination test, passive cutaneous anaphylaxis and precipitin reaction, in all forms tested. Some remarks were made on the possible close relation between the antigenicity of the drug and its affinity to protein.</p>
Amo Type Article
発行日 1970-06
出版物タイトル Acta Medicinae Okayama
24巻
3号
出版者 Okayama University Medical School
開始ページ 323
終了ページ 332
NCID AA00041342
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 4249889
NAID 120002311637
JaLCDOI 10.18926/AMO/32718
フルテキストURL fulltext.pdf
著者 Tada, Hiroshi|
抄録 <p>For the purpose to reveal the changes in stimulatory effect of dibutyryl-cyclic- AMP on erythropoiesis during ontogenetic development, the author studied syntheses of DNA, RNA and protein of erythroid cells in fetal liver, neonatal and adult bone marrows of rats. In the bone marrow of neonatal animals erythropoiesis was stimulated by the intraperitoneal injection of cyclic nucleotide with enhanced DNA, RNA and protein syntheses of erythroid cells. Enhancing effect of dibutyryl-c-AMP on the erythropoiesis decreased gradually with advance of neonatal days. Autoradiographic observations revealed that in erythoid cells isolated from fetal liver and neonatal bone marrows, DNA-, RNA- and protein-snythesis was markedly stimulated by incubating with cyclic nucleotide, but not in those from adult bone marrow. Discussion was made on the changes in the regulatory mechanism of erythropoiesis according to the transition of hematopoietic organs during development.</p>
Amo Type Article
発行日 1974-06
出版物タイトル Acta Medica Okayama
28巻
3号
出版者 Okayama University Medical School
開始ページ 159
終了ページ 171
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 4374048
NAID 120002311750
JaLCDOI 10.18926/AMO/31283
フルテキストURL fulltext.pdf
著者 Tada, Hiroshi| Nakagawa, Toshifumi| Takaiwa, Takashi| Nakagawa, Shojiro|
抄録 <p>The distribution of 2,4-dinitrophenyl (DNP) groups in the draining lymph nodes of guinea pigs 12 h after painting the skin with 2,4-dinitrochlorobenzene (DNCB) was examined by a peroxidase labelled antibody method using antibody against DNP groups. DNP groups were detected on cells that were found mainly in the subcapsular sinus of the lymph nodes. Electron microscopic examination showed DNP groups distributed on the surface of lymphocytes. The significance of these findings is discussed.</p>
キーワード contact sensitivity 2 4-dinitrochlorobenzene dinitrophenyl group peroxidase.
Amo Type Brief Note
発行日 1981-06
出版物タイトル Acta Medica Okayama
35巻
3号
出版者 Okayama University Medical School
開始ページ 215
終了ページ 219
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6457511
Web of Sience KeyUT A1981MD16600007