JaLCDOI 10.18926/AMO/55656
フルテキストURL 72_1_1.pdf
著者 Saito, Yukihiro| Nakamura, Kazufumi| Ito, Hiroshi|
抄録 The number of permanent pacemaker implantations has been increasing due to the aging of populations worldwide and the increase in the numbers of patients with heart diseases. Commercially available mechanical pacemakers are very useful but still have some problems including short battery life, a risk of infection, the absence of physiological autonomic responsiveness, metal allergy, and electronic interference. A biological pacemaker may resolve these problems and regenerate the cardiac pacemaker. Cell-based therapy and gene therapy have been addressed with the goal of solving the challenges of biological pacemaker. However, the clinical application of a biological pacemaker has not yet been realized. Here we discuss the types of cells that can be used for a biological pacemaker and the problems that remain regarding the clinical applications of cell-based therapy.
キーワード cell therapy pluripotent stem cells cardiomyocytes biological pacemaker hyperpolarization activated cyclic nucleotide gated potassium channel 4
Amo Type Review
発行日 2018-02
出版物タイトル Acta Medica Okayama
72巻
1号
出版者 Okayama University Medical School
開始ページ 1
終了ページ 7
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 29463932
フルテキストURL Vasc_Health_Risk_Manag_11_265.pdf
著者 Saito, Yukihiro| Nakamura, Kazufumi| Akagi, Satoshi| Sarashina, Toshihiro| Ejiri, Kentaro| Miura, Aya| Ogawa, Aiko| Matsubara, Hiromi| Ito, Hiroshi|
キーワード apoptosis prostacyclin pulmonary arterial hypertension
備考 学位審査副論文
発行日 2015-05-14
出版物タイトル Vascular Health and Risk Management
11巻
出版者 Dove Medical Press
開始ページ 265
終了ページ 270
ISSN 1176-6344
NCID AA12158664
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
著作権者 https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
論文のバージョン publisher
PubMed ID 25999730
DOI 10.2147/VHRM.S50368
Web of Sience KeyUT 000210424400027
関連URL https://doi.org/10.2147/VHRM.S50368 http://ousar.lib.okayama-u.ac.jp/55246