JaLCDOI 10.18926/AMO/31942
フルテキストURL fulltext.pdf
著者 Nakamoto, Shu| Sadahira, Yoshito| Mori, Masaharu| Awai, Michiyasu|
抄録 <p>We investigated the organ distribution of four types of red blood cells (RBC) preparations: native RBC, asialo-RBC, native ghosts and asialo-ghosts. Intravenously injected asialo-ghosts were rapidly removed from the blood stream and accumulated mainly in the liver 120 min after the injection. Our results suggest that asialo-ghosts are a simple and effective carrier for targeting of drugs to the liver.</p>
キーワード red blood cell ghosts sialidase-treatment orgam distribution targeting to liver.
Amo Type Article
発行日 1986-02
出版物タイトル Acta Medica Okayama
40巻
1号
出版者 Okayama University Medical School
開始ページ 61
終了ページ 64
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 3008506
Web of Sience KeyUT A1986A190200009
JaLCDOI 10.18926/AMO/30673
フルテキストURL fulltext.pdf
著者 Mori, Masaharu| Nakamoto, Shu| Kirizuka, Keizi| Sadahira, Yoshito| Awai, Michiyasu| Seno, Satimaru| Sasaki, Junzo| Utsumi, Kozo|
抄録 <p>Cytochalasin B (CB) treatment induces or accelerates the capping phenomenon in some cells. In Ehrlich ascites tumor cells (EATC) CB treatment apparently induced the capping of Con A binding sites as observed under a fluorescent microscope. However, electron microscopic examinations revealed that the CB treatment did not induce a rearrangement of Con A binding sites, but rather it only induced a change in cell shape. On the contrary, CB treatment inhibited the capping phenomenon induced by treatment with Con A. Electron microscopic observations may give exact information on the distribution of lectin binding sites.</p>
キーワード Ehrlich ascites tumor cell concanvalin A cytochalasin B cap formation
Amo Type Brief Note
発行日 1982-12
出版物タイトル Acta Medica Okayama
36巻
6号
出版者 Okayama University Medical School
開始ページ 483
終了ページ 486
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 7158429
Web of Sience KeyUT A1982PW07500007