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ID 32039
JaLCDOI
フルテキストURL
著者
Yamana, Seizo Okayama University
Nakamura, Zenichi Okayama University
Saito, Yoshihito Okayama University
Yamamoto, Michinori Okayama University
Ofuji, Tadashi Okayama University
抄録

Purification of antilymphocyte antibody (ALA) from patients with systemic lupus erythematosus (SLE) was achieved by immunoabsorption and elution. Human tonsil cells or thymocytes were used as absorbents. Complement dependent microcytotoxicity tests showed that, in comparison to the parent sera, the eluate from tonsil cells was eight times, and that from thymocytes four times, more active. Antinuclear activity was eliminated by elution. The ALA was almost entirely IgM, IgG being involved in only a few cases. IgA lacked cytotoxic activity. ALA was directed at both T- and B-cell surface determinants, which suggests that, in SLE, it has a heterogeneous biological composition.

キーワード
antilymphocyte antibody
systemic lupus erythematosus
purification
Amo Type
Article
発行日
1979-08
出版物タイトル
Acta Medica Okayama
33巻
4号
出版者
Okayama University Medical School
開始ページ
259
終了ページ
267
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID