JaLCDOI 10.18926/AMO/32039
フルテキストURL fulltext.pdf
著者 Yamana, Seizo| Nakamura, Zenichi| Saito, Yoshihito| Yamamoto, Michinori| Ofuji, Tadashi|
抄録 <p>Purification of antilymphocyte antibody (ALA) from patients with systemic lupus erythematosus (SLE) was achieved by immunoabsorption and elution. Human tonsil cells or thymocytes were used as absorbents. Complement dependent microcytotoxicity tests showed that, in comparison to the parent sera, the eluate from tonsil cells was eight times, and that from thymocytes four times, more active. Antinuclear activity was eliminated by elution. The ALA was almost entirely IgM, IgG being involved in only a few cases. IgA lacked cytotoxic activity. ALA was directed at both T- and B-cell surface determinants, which suggests that, in SLE, it has a heterogeneous biological composition.</p>
キーワード antilymphocyte antibody systemic lupus erythematosus purification
Amo Type Article
発行日 1979-08
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 259
終了ページ 267
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 91309
著者 Sarai, Tetsuo| Kawanishi, Koichi| Saito, Yoshihito| Aoi, Katsuyuki| Nishina, Yoshiaki| Ofuji, Tadashi|
発行日 1978-08
出版物タイトル Acta Medica Okayama
資料タイプ 学術雑誌論文