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ID 17710
Eprint ID
17710
フルテキストURL
Thumnail 86_29.pdf 1.33 MB
タイトル(別表記)
Studies on Immunotherapy of Rauscher Leukemia 1 Observation on Splenomegaly, Blood picture, Histopathology and Electron Microscopy
著者
菅 嘉彦 岡山大学医学部平木内科
抄録
Fromalin-treated extract of spleens of BALB/c mice infected with Rauscher leukemia was, used for protection and immunotherapy against Rauscher leukemia. In the group which was vaccinated at the same time with and one week after virus inoculation leukemia was not protected, although mean survival was more prolonged than in control group. In the group which was injected vaccine 6 weeks after virus inoculation 10 percent of mice were induced to remission. Furthermore, in the group which was vaccinated at 3 weeks after virus inoculation, likewise 10 percent of mice were completely protected against leukemia without manifesting any leukemic sign. In leukemic mice peripheral bolod pictures were characterized by marked increase of nucleated cells and presence of erythroblasts and Rauscher cells. Enormous hepatosplenomegaly was due to proliferating reticulum cells and erythroblasts. In mice which were protected against leukemia and induced to remission with vaccines, no abnormal findings were present in either peripheral blood pictures or histological sections of the spleen and liver. With electron microscopy numerous virus particles were observed in the spleen of leukemic mice, but not observed in the spleen of mice which were protected against leukemia and induced to remission.
発行日
1974-02-28
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
86巻
1-2号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
29
終了ページ
38
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/86/1-2/86_1-2_29/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma