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ID 51031
フルテキストURL
著者
Inoue, Kiyomi Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Sakano, Noriko Department of Hygiene, Faculty of Medicine, Kagawa University
Ogino, Keiki Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Sato, Yoshie Perineito Hahatokono Hosp Mothers & Children, Dept Gynecol & Obstet
Wang, Da-Hong Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kubo, Masayuki Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Takahashi, Hidekazu Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kanbara, Sakiko Okayama Univ, Dept Pediat, Grad Sch Med Dent & Pharmaceut Sci
Miyatake, Nobuyuki Department of Hygiene, Faculty of Medicine, Kagawa University
抄録
Serum ceruloplasmin (CP), a marker relevant to copper metabolism, is one of famous inflammation markers with a reduction in Wilson's disease, whereas serum ferritin is a marker relevant to iron metabolism. Recently, ferritin is pointed out to be related with oxidative stress. However, there is still no population research which showed the relation of CP and ferritin. Therefore, we investigated the relationship between CP and ferritin including oxidative stress biomarkers among healthy Japanese (n = 389). We measured serum CP, ferritin, Fe, high-sensitivity C-reactive protein (hs-CRP), and urinary oxidative stress biomarkers [H2O2, 8-hydroxy-2'-deoxyguanosine (8-OHdG), 8-isoprostane] and so on. Subjects showed that age; 41.7 ± 10.0 (year), CP; 31.9 ± 6.8 (mg/dl), ferritin; 123.5 ± 121.0 (ng/ml), hs-CRP; 0.89 ± 2.53 (mg/l), 8-OHdG; 10.2 ± 4.4 [ng/mg creatinine (Cre)] and H2O2; 6.5 ± 10.9 (µM/g Cre), (All data mentioned above were expressed as mean ± SD). CP was significantly and positively correlated with hs-CRP and inversely correlated with ferritin, Fe and 8-OHdG. By a multiple logistic regression analysis, odds ratio of CP according to quartiles of hs-CRP was 4.86, and according to quartiles of 8-OHdG was 0.39 after adjusting for age and other confounding factors. In conclusion, our findings suggest that CP was an antioxidative biomarker which controls oxidative stress, whereas ferritin was a marker which may participate in the generation of oxidative stress.
キーワード
ceruloplasmin
ferritin
8-OHdG
oxidative stress
high-sensitivity C-reactive protein
発行日
2013-03-01
出版物タイトル
Journal of Clinical Biochemistry and Nutrition
52巻
2号
出版者
The Editorial Secretariat of JCBN
開始ページ
160
終了ページ
166
ISSN
0912-0009
NCID
AA10710201
資料タイプ
学術雑誌論文
オフィシャル URL
http://dx.doi.org/10.3164/jcbn.12-122
言語
English
著作権者
© 2013 JCBN
論文のバージョン
publisher
査読
有り
DOI
PubMed ID