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Ikeda, Masashi Nagoya University
Iwata, Nakao Okayama University
Suzuki, Tatsuyo Fujita Health University
Kitajima, Tsuyoshi Fujita Health University
Yamanouchi, Yoshio Fujita Health University School
Kinoshiya, Yoko Fujita Health University
Sekine, Yoshimoto Okayama University
Iyo, Masaomi Okayama University
Harano, Mutsuo Okayama University
Komiyama, Tokutaro Okayama University
Yamada, Mitsuhiko Okayama University
Sora, Ichiro Okayama University
Ujike, Hiroshi Okayama University
Inada, Toshiya Okayama University
Ozaki, Norio Okayama University
Recent evidence suggests that the AKT1-GSK3b signalling cascade partially mediates dopaminedependent behaviours. In relation to the pathophysiology of schizophrenia or methamphetamine (Meth) use disorder, AKT1 is a good candidate gene for such conditions. For schizophrenia, positive associations of SNPs and AKT1 haplotypes were reported in US and Japanese samples. To evaluate the association between AKT1 and Meth-use disorder, we conducted a case-control study of Japanese samples (182 patients and 437 controls). A positive association between a SNP and haplotypes was found, and the ‘signal’ SNP was the same SNP found to be associated with US schizophrenia, but not with Japanese schizophrenia. Our results indicate that AKT1 may play a possible role in the development of Meth-use disorder. Further investigation of these associations, together with evidence from previous animal studies, may open the way to elucidation of the pathophysiology of this condition.
Digital Object Identifier:10.1017/S1461145705005481
Published with permission from the copyright holder. This is a author's copy,as published in International Journal of Neuropsychopharmacology : Protein and Proteomics, Jun 2005, volume 9, issue 1, pp77-81.
Publisher URL: http://dx.doi.org/10.1017/S1461145705005481
Copyright © 2005 CINP.
International Journal of Neuropsychopharmacology : Protein and Proteomics