JaLCDOI 10.18926/AMO/32412
フルテキストURL fulltext.pdf
著者 Shiota, Tetsuya| Watanabe, Akiharu| Takei, Nobuyuki| Hayashi, Shosaku| Obata, Takahiro| Sakata, Tatsuro| Nagashima, Hideo|
抄録 <p>Blood ammonia levels in patients with various liver diseases were determined quantitatively by a simple and rapid method using the Amitest Meter System. The results were compared to those obtained by an enzymatic method and were well correlated. This simple Amitest is also useful in animal experiments, particularly when there is a need to determine blood ammonia levels serially. This paper test was evaluated as being accurate and reliable for clinical and experimental use.</p>
キーワード simple method blood ammonia hyperammonemia liver disease
Amo Type Brief Note
発行日 1983-04
出版物タイトル Acta Medica Okayama
37巻
2号
出版者 Okayama University Medical School
開始ページ 159
終了ページ 162
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6869065
Web of Sience KeyUT A1983QN63900009
JaLCDOI 10.18926/AMO/32406
フルテキストURL fulltext.pdf
著者 Kobayashi, Michio| Watanabe, Akiharu| Nakatsukasa, Harushige| Fujiwara, Masachika| Shiota, Tetsuya| Takei, Nobuyuki| Sakata, Tatsuro| Yamauchi, Yasuhiko| Nagashima, Hideo|
抄録 <p>The prognoses of patients with alcoholic liver cirrhosis were compared between those who continued to drink and those who stopped. Clinical criteria were strictly set so as to control other variables affecting the prognoses. Four-year survival was significantly higher in the patients who stopped drinking than in those who continued to drink. Continued drinking worsens the prognosis of patients with alcoholic liver cirrhosis.</p>
キーワード alcoholic liver cirrhosis prognosis continued drinking stopped drinking alcohol consumption
Amo Type Brief Note
発行日 1983-12
出版物タイトル Acta Medica Okayama
37巻
6号
出版者 Okayama University Medical School
開始ページ 525
終了ページ 527
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6666679
Web of Sience KeyUT A1983RW62800010
JaLCDOI 10.18926/AMO/31264
フルテキストURL fulltext.pdf
著者 Obata, Takahiro| Watanabe, Akiharu| Hayashi, Shosuku| Takei, Nobuyuki| Sakata, Tatsuro| Shiota, Tetsuya| Higashi, Toshihiro| Itoshima, Tatsuya| Nagashima, Hideo|
抄録 <p>Cholestasis with htperbilirubinemia was induced in female, but not male, Sprague-Dawley rats by daily treatment with phalloidin for 7 days. Increases in serum direct bilirubin level and alkaline phosphatase (Al-Pase) activity were observed concomitantpy with diminished bile flow and a decreased output of bile acid and cholesterol. Kidht microscope findings of the liver revealed proliferated bile ductules and enhanced mitosis of hepatocytes.</p>
キーワード phalloidin cholestasis hyperbilirubinemia mitosis bile ductule.
Amo Type Article
発行日 1981-12
出版物タイトル Acta Medica Okayama
35巻
6号
出版者 Okayama University Medical School
開始ページ 411
終了ページ 415
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6459712
Web of Science KeyUT A1981MV25300004
JaLCDOI 10.18926/AMO/31261
フルテキストURL fulltext.pdf
著者 Obata, Takahiro| Watanabe, Akiharu| Hayashi, Shosaku| Takei, Nobuyuki| Sakata, Tatsuro| Shiota, Tetsuya| Higashi, Toshihiro| Itoshima, Tatsuya| Nagashima, Hideo|
抄録 <p>Cholestasis with hyperbilirubinemia was induced in female, but not male, Sprague-Dawley rats by daily treatment with phalloidin for 7 days. Increases in serum direct bilirubin level and alkaline phosphatase (Al-Pase) activity were observed concomitantly with diminished bile flow and a decreased output of bile acid and cholesterol. Light microscope findings of the liver revealed proliferated bile ductules and enhanced mitosis of hepatocytes.</p>
キーワード phalloidin cholestasis hyperbilirubinemia mitosis bile ductule.
Amo Type Article
発行日 1981-12
出版物タイトル Acta Medica Okayama
35巻
6号
出版者 Okayama University Medical School
開始ページ 411
終了ページ 415
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6459712
Web of Sience KeyUT A1981MV25300004
JaLCDOI 10.18926/AMO/30669
フルテキストURL fulltext.pdf
著者 Watanabe, Akiharu| Higashi, Toshihiro| Hayashi, Shosaku| Obata, Takahiro| Sakata, Tatsuro| Takei, Nobuyuki| Shiota, Tetsuya| Nagashima, Hideo|
抄録 <p>The effects of insulin and glucagon administration on serum amino acid levels were investigated in patients with severe liver disease, since simultaneous injection of pancreatic hormones has been recently introduced as a therapeutic approach. The changes in serum amino acid concentrations, as observed 3 h after ceasing a 3 h infusion of insulin and glucagon in 500 ml glucose solution, were an elevation of serum branched chain amino acid (BACA) levels and of the molar ratio of BCAA/aromatic amino acid (AAA) levels in patients with liver cirrhosis. Similar increases of serum BCAA levels during the infusion were also observed in patients with fulminant hepatitis. The results suggest that insulin-glucagon therapy for severe liver disease has no harmful side effects at least with respect to alterations in the serum aminogram.</p>
キーワード glucagon insulin amino acid liver disease
Amo Type Article
発行日 1982-12
出版物タイトル Acta Medica Okayama
36巻
6号
出版者 Okayama University Medical School
開始ページ 441
終了ページ 446
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6760674
Web of Science KeyUT A1982PW07500002
JaLCDOI 10.18926/AMO/30322
フルテキストURL fulltext.pdf
著者 Sakata, Tatsuro|
抄録 <p>Effects of carbon tetrachloride (CCl4) and azathioprine (AZP) on the evolution of hyperplastic liver nodules and foci and hepatocellular carcinoma (HCC) were tested in short- and long-term in vivo experiments. In diethylnitrosamine (DEN)-treated rats, which were fed a N-2-fluorenylacetamide (FAA)-containing diet and additionally treated with repeated CCl4 injections, gamma-glutamyl transpeptidase (gamma-GTP)-positive hyperplastic nodules were markedly developed in the 8th week of the experiment. However, their number and area in liver sections were remarkably small in DEN-treated rats fed a diet containing both FAA and AZP. Increased area of gamma-GTP-positive foci was also observed in the 12th week in DEN-injected rats fed a choline-devoid died alone or treated with repeated doses of CCl4 alone. Hepatocellular carcinoma in DEN-injected rats treated with both FAA and CCl4 was first detected in the 21st week, and the incidence up to the 36th week was very high. However, no hepatocellular carcinoma developed in DEN-injected rats treated with both FAA and AZP. The increased activity of liver aniline hydroxylase observed 12 h after the administration of FAA, AZP or DEN alone was not observed when AZP was administered simultaneously with FAA to DEN-injected rats. The mechanisms of the effects of CCl4 and AZP on hepatocarcinogenesis are discussed with special reference to drug interaction.</p>
キーワード hepatocellular carcinoma hyperplastic liver nodule ?-glitamyl transpeptidase azathioprine carbon tetrachloride
Amo Type Article
発行日 1984-12
出版物タイトル Acta Medica Okayama
38巻
6号
出版者 Okayama University Medical School
開始ページ 511
終了ページ 524
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6524446
Web of Science KeyUT A1984TX98000004