| JaLCDOI | 10.18926/AMO/31646 |
|---|---|
| フルテキストURL | fulltext.pdf |
| 著者 | Kohka, Hideo| Iwagaki, Hiromi| Yoshino, Tadashi| Kobashi, Kenta| Saito, Shinnya| Isozaki, Hiroshi| Takakura, Norihisa| Tanaka, Noriaki| |
| 抄録 | <p>Corticoids are well known for their immunosuppressive properties. Interleukin-10 (IL-10) is an intrinsic antiinflammatory peptide in immune diseases, originally identified as cytokine synthesis inhibitory factor. We examined the effect of hydrocortisone sodium succinate (HSS) on the production of IL-10 by human peripheral blood mononuclear cells (PBMCs). PBMCs from healthy volunteers and cancer-burden patients were preincubated separately with or without HSS for 1 h, then stimulated with 5 microg/ml lipopolysaccharide (LPS). Production of IL-10 by human PBMCs was detected with LPS stimulation and its production was higher in cancer-burden patients than in normal volunteers, although this was not statistically significant. HSS suppressed production of IL-10 by LPS-stimulated PBMCs in a dose-dependent manner both in normal volunteers and in cancer-burden patients. These results indicate that, in addition to their antiinflammatory properties, corticoids act to restore the immunosuppressive states even in cancer-burden states</p> |
| キーワード | steroid interleukin-10 cancer-burden state |
| Amo Type | Article |
| 発行日 | 1999-02 |
| 出版物タイトル | Acta Medica Okayama |
| 巻 | 53巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 55 |
| 終了ページ | 59 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | English |
| 論文のバージョン | publisher |
| 査読 | 有り |
| Web of Sience KeyUT | 000078897700009 |