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ID 31646
JaLCDOI
フルテキストURL
著者
Kohka, Hideo Okayama University
Iwagaki, Hiromi Okayama University
Yoshino, Tadashi Okayama University
Kobashi, Kenta Okayama University
Saito, Shinnya Okayama University
Isozaki, Hiroshi Okayama University
Takakura, Norihisa Okayama University
Tanaka, Noriaki Okayama University
抄録

Corticoids are well known for their immunosuppressive properties. Interleukin-10 (IL-10) is an intrinsic antiinflammatory peptide in immune diseases, originally identified as cytokine synthesis inhibitory factor. We examined the effect of hydrocortisone sodium succinate (HSS) on the production of IL-10 by human peripheral blood mononuclear cells (PBMCs). PBMCs from healthy volunteers and cancer-burden patients were preincubated separately with or without HSS for 1 h, then stimulated with 5 microg/ml lipopolysaccharide (LPS). Production of IL-10 by human PBMCs was detected with LPS stimulation and its production was higher in cancer-burden patients than in normal volunteers, although this was not statistically significant. HSS suppressed production of IL-10 by LPS-stimulated PBMCs in a dose-dependent manner both in normal volunteers and in cancer-burden patients. These results indicate that, in addition to their antiinflammatory properties, corticoids act to restore the immunosuppressive states even in cancer-burden states

キーワード
steroid
interleukin-10
cancer-burden state
Amo Type
Article
発行日
1999-02
出版物タイトル
Acta Medica Okayama
53巻
1号
出版者
Okayama University Medical School
開始ページ
55
終了ページ
59
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
Web of Sience KeyUT