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ID 53137
フルテキストURL
著者
Mizuki, Yutaka Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neuropsychiat
Takaki, Manabu Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neuropsychiat
Okahisa, Yuko Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neuropsychiat
Sakamoto, Shinji Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neuropsychiat
Kodama, Masafumi Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neuropsychiat
Ujike, Hiroshi Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neuropsychiat
Uchitomi, Yosuke Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neuropsychiat
抄録
ObjectiveThe human Rho guanine nucleotide exchange factor 11 (ARHGEF11) gene is one of the candidate genes for type 2 diabetes mellitus (T2DM). ARHGEF11 is mapped to chromosome 1q21, which has susceptible risk loci for T2DM and schizophrenia. We hypothesized that ARHGEF11 contributes to the pathogenesis of schizophrenia. MethodWe selected eight single nucleotide polymorphisms of ARHGEF11 that had significant associations with T2DM for a case-control association study of 490 patients with schizophrenia and 500 age-matched and sex-matched controls. ResultsWe did not find any differences in allelic, genotypic associations, or minor allele frequencies with schizophrenia. Analysis of the rs6427340-rs6427339 haplotype and the rs822585-rs6427340-rs6427339 haplotype combination provided significant evidence of an association with schizophrenia (global permutations p=0.00047 and 0.0032, respectively). C-C of the rs6427340-rs6427339 haplotype and A-C-C of the rs822585-rs6427340-rs6427339 haplotype carried higher risk factors for schizophrenia (permutation p=0.0010 and 0.0018, respectively). A-C-T of the rs822585-rs6427340-rs6427339 haplotype had a possible protective effect (permutation p=0.031). ConclusionThese results provide new evidence that ARHGEF11 may constitute a risk factor for schizophrenia.
キーワード
ARHGEF11
case-control study
schizophrenia
type 2 diabetes mellitus
備考
This is the accepted version of the following article: FULLCITE, which has been published in final form at http://dx.doi.org/10.1002/hup.2435
発行日
2014-11
出版物タイトル
Human Psychopharmacology: Clinical and Experimental
29巻
6号
開始ページ
552
終了ページ
558
資料タイプ
学術雑誌論文
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/53126
言語
English
著作権者
© 2014 John Wiley & Sons, Ltd.
論文のバージョン
author
査読
有り
DOI