著者 Hishikawa, Tomohito| Sugiu, Kenji| Murai, Satoshi| Takahashi, Yu| Kidani, Naoya| Nishihiro, Shingo| Hiramatsu, Masafumi| Date, Isao| Satow, Tetsu| Iihara, Koji| Sakai, Nobuyuki| JR-NET2 and JR-NET3 study groups.|
キーワード Complication Embolization Intracranial tumor Risk factors
備考 This fulltext will be available in Aug 2020|
発行日 2019-06-07
出版物タイトル Acta Neurochirurgica
161巻
8号
出版者 Springer Nature
開始ページ 1675
終了ページ 1682
ISSN 00016268
NCID AA0050885X
資料タイプ 学術雑誌論文
言語 English
OAI-PMH Set 岡山大学
論文のバージョン author
PubMed ID 31172282
DOI 10.1007/s00701-019-03970-w
Web of Science KeyUT 000475688800023
関連URL isVersionOf https://doi.org/10.1007/s00701-019-03970-w
JaLCDOI 10.18926/AMO/30781
フルテキストURL fulltext.pdf
著者 Sakai, Nobuyuki| Okada, Yoshio| Tsuji, Takao|
抄録 <p>The serum levels of the carbohydrate antigen sialyl Lewis X (SLEX) increase in liver diseases (Sunayama T, Okada Y, Tsuji T., J Hepatol 1994; 19: 451-458). However, it is not known whether the increased serum SLEX levels are associated with the increased levels of its carrier molecules and/or the increased density of SLEX per carrier molecule. By using of rabbit antibody against an SLEX-positive fraction from HepG2 culture supernatant, we developed an enzyme-linked immunosorbent assay to determine the serum levels of the carrier molecules of SLEX (CM<sub>SLEX</sub>). The CM<sub>SLEX</sub>-levels in patients with hepatocellular carcinoma were significantly higher than those of normal controls (P &#60; 0.001) and benign chronic liver diseases, i.e., chronic active hepatitis, mild and severe form, and liver cirrhosis (P &#60; 0.05). Patients with chronic persistent hepatitis and chronic active hepatitis, mild form, had higher CM<sub>SLEX</sub>-levels than normal controls (P &#60; 0.05). The serum CM<sub>SLEX</sub>-levels did not differ significantly among benign liver diseases. We concluded that serum CM<sub>SLEX</sub>-levels increase nonspecifically in liver diseases. This is a possible molecular mechanism for the increased serum SLEX levels in liver diseases.</p>
キーワード glycoprotein carbohydrate antigen chronic liver disease hepatocellular carcinoma
Amo Type Article
発行日 1997-04
出版物タイトル Acta Medica Okayama
51巻
2号
出版者 Okayama University Medical School
開始ページ 79
終了ページ 85
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 9142344
Web of Science KeyUT A1997WX19600004