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ID 31746
JaLCDOI
フルテキストURL
著者
Shiozaki, Shigehiro Okayama University
Sakagami, Kenichi Okayama University
Orita, Kunzo Okayama University
抄録

We administered serum fractions obtained from cancer patients by double-filtration plasmapheresis (DFPP) to cancer-bearing mice to examine the effects on tumor growth and metastasis. Fraction 1 (whole plasma), fraction 2 (a plasma fraction containing substances with higher particle size), fraction 3 (a plasma fraction containing substances with smaller particle size) and saline were administered intravenously to cancer-bearing mice for 10 days following the inoculation of tumor cells. The tumor growth and metastasis in mice administered fraction 2 was far more rapid than that in the control mice. On the other hand, tumor growth in mice administered fraction 3 was significantly delayed compared with that in mice injected with fraction 2. These results suggest that factors in the higher particle-size fraction of cancer patients' sera promote the growth and the metastasis of tumors in mice, and that DFPP, which remove these factors, is an effective therapy against cancer.

キーワード
doble-filtration plasmapheresis
immunosuppressive factors
cancer thrapy
Amo Type
Article
発行日
1987-04
出版物タイトル
Acta Medica Okayama
41巻
2号
出版者
Okayama University Medical School
開始ページ
63
終了ページ
69
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT