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ID 32844
JaLCDOI
フルテキストURL
Thumnail fulltext.pdf 2.71 MB
著者
Honda, Mayumi Okayama University
Yamada, Teruo Okayama University
Nomura, Takako Okayama University
Miki, Yukari Okayama University
Kande, Shigeto Okayama University
Seki, Akihiko Okayama University
Sasaki, Junzou Okayama University
抄録

Differential, histochemical and immunohistochemical changes were observed in hepatocytes from immediately to 7 days after isoflurane or sevoflurane exposure (at H 0 to on Day 7) to study the process of development and recovery in anesthetic-induced hepatic injury. A total of 570 7-week-old male Sprague-Dawley rats with or without phenobarbital treatment were exposed to isoflurane or sevoflurane in 100%, 21%, or 10% oxygen, or to 10% oxygen alone for 2h. In phenobarbital-treated rats, hepatocytes both with and without anesthetic exposure markedly changed in 10% oxygen at H 0. Glycogen and ribosomal ribonucleic acid (rRNA) disappeared at H 0 and at H 6, respectively, and at H 6, AST levels in the blood rose. From H 6 to Day 1, necrosis developed more markedly and widely in zone 3 hepatocytes exposed to anesthetics in 10% oxygen than in those exposed to oxygen alone. All degenerated tissues had returned to normal levels by day 7. Recovery of the hepatolobular structure may be attributed to rearrangement of remaining hepatocytes in the portal vein area. Both the disappearance of glycogen and rRNA and the increase in blood AST levels after exposure to isoflurane or sevoflurane are considered to be factors contributing to the induction of necrosis around the central vein. The grade of isoflurane-induced hepatic injury was found to be significantly higher than that of sevoflurane.

キーワード
isoflurane
sevoflurane
histochemistry
hypoxia
hepatic injury
Amo Type
Article
発行日
2003-02
出版物タイトル
Acta Medica Okayama
57巻
1号
出版者
Okayama University Medical School
開始ページ
1
終了ページ
12
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT