JaLCDOI 10.18926/AMO/41323
フルテキストURL 64_6_375.pdf
著者 Kariya, Shin| Cureoglu, Sebahattin| Fukushima, Hisaki| Morita, Norimasa| Baylan, Muzeyyen Y.| Maeda, Yukihide| Nishizaki, Kazunori| Paparella, Michael M.|
抄録 This study examined whether pathological findings were present in cochlear vessels for patients with diabetes mellitus. Twenty-six temporal bones from 13 patients with type 1 diabetes mellitus and 40 temporal bones from 20 patients with type 2 diabetes mellitus were examined. Type 2 diabetic temporal bones were divided into 2 groups according to diabetic management (22 temporal bones with insulin therapy, and 18 with oral hypoglycemic drugs). Age-matched normal control temporal bones were also selected. The vessel wall thickness in the cochlear spiral modiolar artery was measured under a light microscope, and the vessel wall ratio (vessel wall thickness/outer diameter of the vessel×100) was calculated. The vessel wall thickness and vessel wall ratio in type 1 diabetes mellitus were significantly greater than in normal controls. Type 2 diabetic patients with insulin therapy showed significantly greater vessel wall thickness and vessel wall ratios than controls. In type 2 diabetes mellitus, the vessel wall thickness and vessel wall ratio were greater in patients treated with insulin therapy than in those treated with oral hypoglycemic agents. Type 2 diabetic patients with insulin therapy showed an increased vessel wall thickness and vessel wall ratio compared to patients with type 1 diabetes mellitus. In conclusion, the cochlea in patients with diabetes mellitus shows circulatory disturbance compared to age-matched normal controls.
キーワード diabetes mellitus temporal bone cochlear spiral modiolar artery hearing loss
Amo Type Original Article
発行日 2010-12
出版物タイトル Acta Medica Okayama
64巻
6号
出版者 Okayama University Medical School
開始ページ 375
終了ページ 383
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 21173807
Web of Sience KeyUT 000285664200004
著者 Kariya, Shin| Nishizaki, kazunori| Akagi, Hirofumi| Paparella, Michael M.|
発行日 2004-11
出版物タイトル Journal of Laryngology & Otology
118巻
11号
資料タイプ 学術雑誌論文