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ID 31969
JaLCDOI
フルテキストURL
著者
Piao, Cheng-Yu Okayama University
Fujioka, Shin-ichi Okayama University
Iwasaki, Yoshiaki Okayama University ORCID 科研費研究者番号
Fujio, Kozo Okayama Hepatitis Research Group
Kaneyoshi, Toshihiko Okayama Hepatitis Research Group
Araki, Yasuyuki Okayama Hepatitis Research Group
Hashimoto, Kuniaki Okayama Hepatitis Research Group(OHRG)
Senoh, Tomonori Okayama Hepatitis Research Group
Terada, Ryo Okayama Hepatitis Research Group
Nishida, Tomohiro Okayama University
Kobashi, Haruhiko Okayama University
Sakaguchi, Kohsaku Okayama University
Shiratori, Yasushi Okayama University
抄録

Lamivudine is widely used to treat patients with hepatitis B. However, the outcomes in patients with hepatocellular carcinoma (HCC) treated with lamivudine have not been established. This study was conducted to evaluate the outcomes of lamivudine treatment for patients with HCC using an untreated, matched control group. Thirty patients with controlled HCC orally received lamivudine. As controls, 40 patients with HCC who were not treated with lamivudine and matched for clinical features were selected. The lamivudine-treated and untreated groups were compared with respect to changes in liver function, HCC recurrence, survival, and cause of death. In the lamivudine-treated group, there was significant improvement in the Child-Pugh score at 24 months after starting treatment, while no improvement was observed in the untreated group. There was no significant difference in the cumulative incidence of HCC recurrence and survival between the groups. However, there was a significant difference in the cumulative incidence of death due to liver failure (P= 0.043). A significant improvement in liver function was achieved by lamivudine treatment, even in patients with HCC. These results suggest that lamivudine treatment for patients with HCC may prevent death due to liver failure. Further prospective randomized studies using a larger number of patients are required.

キーワード
liver failure
Child-Pughscore
recurrence
survival
resistant mutant
Amo Type
Article
発行日
2005-10
出版物タイトル
Acta Medica Okayama
59巻
5号
出版者
Okayama University Medical School
開始ページ
217
終了ページ
224
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT