JaLCDOI 10.18926/AMO/31506
フルテキストURL fulltext.pdf
著者 Takahashi, Isao| Ohmoto, Eijiro| Aoyaka, Shigeo| Takizawa, Michihiro| Oda, Yasuhiro| Nonaka, Kenichi| Nakada, Hiroyuki| Yorimitsu, Seiichi|
抄録 <p>Age-related alterations in the host defense system have been vigorously investigated because of increased susceptibility to infection and neoplasms in the aged. Although monocyte-macrophages form a major part of the cellular defense against microorganisms, the majority of investigations has been limited to neutrophils and lymphocytes. The present study, designed to determine the influence of age on mononuclear phagocytes, revealed no significant decrease in the absolute number of blood monocytes, but did reveal a tendency for the chemiluminescence of blood monocytes to decrease (p less than 0.10) and a significant decrease in the numbers of macrophage precursors (p less than 0.05) in the aged (over 70 year old), in comparison with controls (under 40 years old). On the basis of these findings, functional alterations of monocyte-macrophages seem to participate in the increased susceptibility to infection in the aged.</p>
キーワード monocyte chemiluminescence macrophage precursor monocyte function in the aged susceptibility to infection in the aged
Amo Type Article
発行日 1985-12
出版物タイトル Acta Medica Okayama
39巻
6号
出版者 Okayama University Medical School
開始ページ 447
終了ページ 451
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 4091040
Web of Sience KeyUT A1985AWT4000004
JaLCDOI 10.18926/AMO/30319
フルテキストURL fulltext.pdf
著者 Takahashi, Isao| Oda, Yasuhiro| Lai, Minyu| Fukumoto, Mitsuhiro| Nishimura, Masataka| Yorimitsu, Seiichi| Kitajima, Koichi| Kimura, Ikuro|
抄録 <p>The combined effect of human lymphoblastoid interferon (HLBI) and anticancer agents on the growth of MOLT-4 was studied in vitro. The interferon showed a strikingly synergistic interaction in combination with aclarubicin, cytosine arabinoside or prednisolone. It was moderately synergistic in combination with adriamycin or 5-fluorouracil and tended to show additive effects with daunorubicin or vincristine. In vitro studies of combination chemotherapy with interferon and anticancer agents should yield valuable information as to the best combination for man.</p>
キーワード human lymphoblastoid interferon in vitro chemotherapy interaction of anticancer agents
Amo Type Article
発行日 1984-12
出版物タイトル Acta Medica Okayama
38巻
6号
出版者 Okayama University Medical School
開始ページ 501
終了ページ 504
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6335349
Web of Sience KeyUT A1984TX98000002