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ID 32656
JaLCDOI
フルテキストURL
著者
Hada, Hajime Okayama University
Koide, Norio Okayama University
Hanafusa, Tadashi Okayama Univeristy
Sakaguchi, Kosaku Okayama University
Shinji, Toshiyuki Okayama University
Sasaki, Shunsuke Okayama University
Oka, Takahiko Okayama University
Takayama, Niro Okayama University
Yumoto, Yasuhiro Okayama University
Tsuji, Takao Okayama University
抄録

We detected an antibody to HCV envelope protein (E1) in sera of patients with HCV-related chronic liver diseases (20 patients with chronic hepatitis and 5 patients with liver cirrhosis) by Western blotting using the fusion protein of E1 envelope protein and beta-galactosidase as an antigen. The antibody to HCV E1 (anti-HCV E1) was detected in 8 (42%) of 19 patients positive for HCV-RNA (16 were positive and 3 were negative for antibody to C100-3) and in 1 (17%) of 6 patients negative for HCV-RNA but positive for antibody to C100-3. HCV-RNA was detected in 8 (89%) of 9 anti-HCV E1 positive sera. The value of alanine aminotransferase was significantly higher in patients positive for anti-HCV E1 than in patients negative for the antibody. Although an antibody to the envelope protein of HCV is suspected to be one of the candidates of virus-neutralizing antibodies, our results suggest this hypothesis appears to be unlikely.

キーワード
hepatitis C virus
envelope
antibody
Western blotting
Amo Type
Article
発行日
1992-10
出版物タイトル
Acta Medica Okayama
46巻
5号
出版者
Okayama University Medical School
開始ページ
367
終了ページ
370
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT