著者 Okada, Soji| Yagyu, Fumito| Kawanishi, Koichi| Ofuji, Tadashi|
発行日 1977-06
出版物タイトル Acta Medica Okayama
31巻
3号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/32052
フルテキストURL fulltext.pdf
著者 Makino, Hirofumi| Ota, Zensuke| Takaya, Yasumasa| Kida, Keiko| Miyoshi, Akira| Hiramatsu, Makoto| Takahashi, Kayo| Ofuji, Tadashi|
抄録 <p>The tubular basement membrane (TBM) (i.e. tubular basal lamina) of rat kidney was shown to be a fine meshwork by electron microscopy after negative staining. Strands of the meshwork formed a regular three dimensional lattice work. The pores of the meshwork were polygonal. There were two main pore sizes: one approximately 30 A in diameter, the other 42--60 A. In view of our previous observation that glomerular and alveolar basement membranes were made up fine meshwork, it is quite possible that the basement membranes of other organs are also made up such fine meshwork.</p>
キーワード renal tubular basement membrane mesh work structure pore negative staining electron micro scopy
Amo Type Brief Note
発行日 1979-04
出版物タイトル Acta Medica Okayama
33巻
2号
出版者 Okayama University Medical School
開始ページ 133
終了ページ 136
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 89787
NAID 120002312032
著者 Hiraki, Kiyoshi| Ofuji, Tadashi| Sunami, Hiroshi| Ota, Zensuke| Kitajima, Koichi| Shinagawa, Koji| Kibata, Masayoshi| Miyoshi, Isao| Hanazawa, Atsumasa|
発行日 1963-02
出版物タイトル Acta Medicinae Okayama
17巻
1号
資料タイプ 学術雑誌論文
著者 Hiraki, Kiyoshi| Ofuji, Tadashi| Sunami, Hiroshi|
発行日 1956-07
出版物タイトル Acta Medicinae Okayama
10巻
3号
資料タイプ 学術雑誌論文
著者 Ofuji, Tadashi| Yamachika, Yukio| Fukuda, Genjiro| Kamura, Junta| Kotani, Saburo| Ota, Zensuke| Kitajima, Koichi|
発行日 1959-06
出版物タイトル Acta Medicinae Okayama
13巻
2号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/30561
フルテキストURL fulltext.pdf
著者 Miyoshi, Masanori| Nakashima, Yusaku| Hirakawa, Shuzo| Mitsunaga, Mikio| Nakagawa, Osamu| Miura, Hiroshi| Suzuki, Shinya| Ofuji, Tadashi|
抄録 <p>Function of pituitary-thyroid axis was studied in rats with experimentally induced thyroiditisWistar strain female rats were immunized with homologous thyroid extract in Freund's complete adjuvant and with simultaneous intradermal injection of pertussis vaccine concentrate. They received booster shots at the first and third week after the initial immunization. Serum thyroid hormones and TSH were measured just before, and at weekly intervals after, the initial immunization. Histological examination of the thyroid gland at the second week after immunization showed slight infiltration of macrophages in the thyroid follicles. From the third to the fourth week, massive lymphoid cell infiltration and destruction of follicular architecture developed in all immunized rats. Serum R3 levels slightly decreased during the second week, increased transiently during the third week, then decreased again thereafter. Serum T4 levels decreased slightly durinf the fourth week. Serum TSH levels were not elevated significantly during the third week, but the response to TRH was significantly increased at this time. Basal TSH levels were increased during the fourth week. The TRH test was a sensitive method capable of detecting minimal failure of thyroid function undetected by other routine measuremens of thyroid hormones and TSH.</p>
キーワード thyroid function thyrotropin (TSH) experimental thyroiditis thyroid hormones.
Amo Type Article
発行日 1980-02
出版物タイトル Acta Medica Okayama
34巻
1号
出版者 Okayama University Medical School
開始ページ 11
終了ページ 17
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6446835
Web of Science KeyUT A1980JS13800002
著者 Nishiya, Koji| Yamana, Seizo| Yano, Keisuke| Ensako, Katuhide| Fujiwara, Tadaaki| Ofuji, Tadashi|
発行日 1974-10
出版物タイトル Acta Medica Okayama
28巻
5号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/32053
フルテキストURL fulltext.pdf
著者 Hashimoto, Kozo| Yunoki, Sho| Hosogi, Hidemi| Takahara, Jiro| Ofuji, Tadashi|
抄録 <p>Biologically active peptides and neurotransmitter substances were added to anterior pituitary cell cultures to examine the presence of corticotropin releasing factor (CRF)-like activity. Hypothalamic extract (HE) induced significant dose-related increase of ACTH, and the lowest effective dose was 0.01 HE/ml. Other tested substances including luteinizing hormone-releasing hormone, thyrotropin releasing hormone, melanocyte stimulating hormone release inhibiting factor, somatostatin, substance P, neurotensin, beta-endorphin. leu-enkephalin, met-enkephalin, bradykinin, norepinephrine, dopamine, serotonin, acetylcholine, histamine, gamma-amino butyric acid or gamma-hydroxy butyric acid showed no CRF-like activity. Relatively high doses of lysine vasopressin, arginine vasopressin and angiotensin II increased the release of ACTH in pituitary cell cultures, but the maximal ACTH response was markedly less than with HE. These results indicate that cultured anterior pituitary cells are sensitive and fairly specific in detecting CRF(s) comparing with other detecting procedures.</p>
キーワード pituitary cell cultures corticotropin releasing factor ACTH neuropeptides neurotransmitter substances
Amo Type Article
発行日 1979-04
出版物タイトル Acta Medica Okayama
33巻
2号
出版者 Okayama University Medical School
開始ページ 81
終了ページ 90
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 38634
NAID 120002311394
著者 Nishiya, Koji| Yamana, Seizo| Sarai, Tetsuo| Ota, Zensuke| Ofuji, Tadashi|
発行日 1976-04
出版物タイトル Acta Medica Okayama
30巻
2号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/32075
フルテキストURL fulltext.pdf
著者 Mitsunaga, Mikio| Hasegawa, Kan| Nakagawa, Osamu| Nakashima, Yusaku| Miyoshi, Masanori| Suzuki, Shinya| Ofuji, Tadashi|
抄録 <p>A case of a 40-year-old woman who was suffering from painless thyroiditis with recurrent transient thyrotoxicosis is reported. Acute exacerbations occurred four times during the past ten years, two after delivery and two after catching a cold. Serum thyroid hormones increased, though radioiodine uptake by the thyroid was very low and no inflammatory signs were observed. The histological findings of the thyroid were of atypical thyroiditis and not consistent with either chronic lymphocytic thyroiditis or subacute thyroiditis. Tanned sheep red cell hemagglutination titers for anti-thyroglobulin antibodies (TRC) and for anti-microsomal antibodies (MHA) were negative or low. The disease seems to be rare and the pathophysiology and etiology are discussed.</p>
キーワード recurrent transient thyrotoxicosis painless thyroiditis hyper-thyroiditis subacute thyroiditis chronic lymphocytic thyroiditis
Amo Type Article
発行日 1979-02
出版物タイトル Acta Medica Okayama
33巻
1号
出版者 Okayama University Medical School
開始ページ 43
終了ページ 51
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 155981
JaLCDOI 10.18926/AMO/32039
フルテキストURL fulltext.pdf
著者 Yamana, Seizo| Nakamura, Zenichi| Saito, Yoshihito| Yamamoto, Michinori| Ofuji, Tadashi|
抄録 <p>Purification of antilymphocyte antibody (ALA) from patients with systemic lupus erythematosus (SLE) was achieved by immunoabsorption and elution. Human tonsil cells or thymocytes were used as absorbents. Complement dependent microcytotoxicity tests showed that, in comparison to the parent sera, the eluate from tonsil cells was eight times, and that from thymocytes four times, more active. Antinuclear activity was eliminated by elution. The ALA was almost entirely IgM, IgG being involved in only a few cases. IgA lacked cytotoxic activity. ALA was directed at both T- and B-cell surface determinants, which suggests that, in SLE, it has a heterogeneous biological composition.</p>
キーワード antilymphocyte antibody systemic lupus erythematosus purification
Amo Type Article
発行日 1979-08
出版物タイトル Acta Medica Okayama
33巻
4号
出版者 Okayama University Medical School
開始ページ 259
終了ページ 267
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 91309
著者 Okada, Soji| Kawanishi, Koichi| Ofuji, Tadashi|
発行日 1974-08
出版物タイトル Acta Medica Okayama
28巻
4号
資料タイプ 学術雑誌論文
著者 Kawanishi, Koichi| Goto, Akio| Ishida, Toshihiko| Kawamura, Ko| Nishina, Yoshiaki| Machida, Shuji| Yamamoto, Shinro| Ofuji, Tadashi|
発行日 1978-08
出版物タイトル Acta Medica Okayama
32巻
4号
資料タイプ 学術雑誌論文
著者 Hiraki, Kiyoshi| Ofuji, Tadashi| Watari, Zenji|
発行日 1956-07
出版物タイトル Acta Medicinae Okayama
10巻
3号
資料タイプ 学術雑誌論文
著者 Yamamoto, Michio| Tanimoto, Junichi| Kojima, Sumikazu| Nobuki, Shigeo| Hagitani, Akira| Iguchi, Yoshiko| Akagi, Eiko| Ofuji, Tadashi| Asaka, Takakazu| Kamura, Junta| Shibata, Tsuneo|
発行日 1960-04
出版物タイトル Acta Medicinae Okayama
14巻
1号
資料タイプ 学術雑誌論文
著者 Yamana, Seizo| Matsueda, Hideki| Ezawa, Hidemitsu| Miyake, Susumu| Katsuyama, Shunsaku| Ofuji, Tadashi|
発行日 1978-12
出版物タイトル Acta Medica Okayama
32巻
6号
資料タイプ 学術雑誌論文
著者 Sarai, Tetsuo| Kawanishi, Koichi| Saito, Yoshihito| Aoi, Katsuyuki| Nishina, Yoshiaki| Ofuji, Tadashi|
発行日 1978-08
出版物タイトル Acta Medica Okayama
32巻
4号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/31274
フルテキストURL fulltext.pdf
著者 Makino, Hirofumi| Takaoka, Michio| Komoda, Keizo| Tokuyama, Kiyoyuki| Ota, Zensuke| Ofuji, Tadashi| Kaneshige, Tetsuji|
抄録 <p>Masugi nephritis was induced in rats by a single intravenous injection of rabbit anti-rat kidney serum, and studied with a scanning electron microscope. A characteristic finding was the presence of white cells, probably polymorphonuclear leukocytes, with many microspikes which penetrated through degenerated glomerular endothelial cells to be in direct contact with the glomerular basement membrane. This finding confirms the pathogenic role of leukocytes in glomerulonephritis induced by anti-glomerular basement membrane antibody.</p>
キーワード Masugi nephritis scanning electron microscopy leukocyte.
Amo Type Brief Note
発行日 1981-11
出版物タイトル Acta Medica Okayama
35巻
5号
出版者 Okayama University Medical School
開始ページ 373
終了ページ 376
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6459000
Web of Sience KeyUT A1981MS42400007
著者 Ogawa, Norio| Miyoshi, Masanori| Takahara, Jiro| Ofuji, Tadashi|
発行日 1975-10
出版物タイトル Acta Medica Okayama
29巻
5号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/30709
フルテキストURL fulltext.pdf
著者 Okada, Soji| Miyai, Yooichiro| Ofuji, Tadashi|
抄録 <p>The patient was a 37-year-old female teacher with hyperemesis diabeticorum and juvenile Type-I diabetes. At the age of 29 years, nausea and vomiting developed and secured at nearly weekly intervals. She was started on clotiazepam (15 mg/day). The vomiting was cured and psychological improvement was evident; her anxiety about diabetes was markedly reduced. An X-ray examination after the administration of clotiazepam showed that she was entirely free from marked hypoperistalsis and the severe retention of gastric contents which had been present before this treatment. The present case is a clear example of stress closely related to the pathogenesis of hyperemesis diabeticorum.</p>
キーワード antianxiety drug hyperemesis diabeticorum
Amo Type Brief Note
発行日 1982-02
出版物タイトル Acta Medica Okayama
36巻
1号
出版者 Okayama University Medical School
開始ページ 81
終了ページ 84
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6121462
Web of Science KeyUT A1982NE20000010