JaLCDOI 10.18926/AMO/31293
フルテキストURL fulltext.pdf
著者 Hashimoto, Kozo| Ohno, Norihito| Aoki, Yoshiyuki| Kageyama, Jingo| Takahara, Jiro| Ofuji, Tadashi|
抄録 <p>The distribution of corticotropin releasing factor (CRF) and arginine vasopressin (AVP) in hypothalamic nuclei were examined in control and estrogen-treated female rats. CRF activity was measured using monolayer cultured rat anterior pituitary cells and AVP by radioimmunoassay. Hypothalamic nuclei were punched out according to the method of Palkovits. The distribution of CRF activity in 5 different hypothalamic nuclei was similar to that of AVP in intact female rats. CRF activity in hypothalamic nuclei, pituitary ACTH content and plasma ACTH levels in estrogen-treated rats were not significantly different from those in control rats. However, significant elevation of AVP content was observed in the supraoptic and paraventricular nuclei of estrogen-treated rats. These results indicate that CRF and AVP are distributed in similar hypothalamic nuclei, but that they are not identical.</p>
キーワード corticotropin releasing factor (CRF) arginine vasopressin (AVP) hypothalamic nucler.
Amo Type Article
発行日 1981-02
出版物タイトル Acta Medica Okayama
35巻
1号
出版者 Okayama University Medical School
開始ページ 37
終了ページ 43
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6266205
Web of Sience KeyUT A1981LH76300004
著者 Nishiya, Koji| Yamana, Seizo| Sarai, Tetsuo| Ota, Zensuke| Ofuji, Tadashi|
発行日 1976-04
出版物タイトル Acta Medica Okayama
30巻
2号
資料タイプ 学術雑誌論文
著者 Yamamoto, Michio| Tanimoto, Junichi| Kojima, Sumikazu| Nobuki, Shigeo| Hagitani, Akira| Iguchi, Yoshiko| Akagi, Eiko| Ofuji, Tadashi| Asaka, Takakazu| Kamura, Junta| Shibata, Tsuneo|
発行日 1960-04
出版物タイトル Acta Medicinae Okayama
14巻
1号
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/32035
フルテキストURL fulltext.pdf
著者 Miyoshi, Akira| Makino, Hirofumi| Hiramatsu, Makoto| Takahashi, Kayo| Yamane, Yukio| Takahara, Jiro| Suzuki, Shinya| Ota, Zensuke| Ofuji, Tadashi| Takehisa, Yoshiaki|
抄録 <p>A 26-year-old female with Bartter's syndrome associated with Graves' disease is reported. This patient had a history of Graves' disease from the age of 22 and anti-thyroid drug (Methimazole) had been administered for 2 years. Thyroid function returned to normal but general fatigue and polyuria continued. Hypokalemia was diagnosed at 25 years of age and she was referred to our hospital for evaluation. Blood pressure was normal and laboratory data revealed normal thyroid function, hypokalemic alkalosis, high plasma renin activity and high plasma aldosterone concentration. She showed normal pressor sensitivity to norepinephrine infusion, grossly diminished pressor sensitivity to exogenous angiotensin II infusion compared with the normal. A renal biopsy specimen showed juxtaglomerular cell hyperplasia. Electron microscopy confirmed lacis cell (agranular cell) proliferation.</p>
キーワード Bartter's syndrome juxtaglomerular cell hyperplasia secondary aldosteronism plasma renin activity
Amo Type Article
発行日 1979-08
出版物タイトル Acta Medica Okayama
33巻
4号
出版者 Okayama University Medical School
開始ページ 305
終了ページ 314
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 158951
JaLCDOI 10.18926/AMO/32039
フルテキストURL fulltext.pdf
著者 Yamana, Seizo| Nakamura, Zenichi| Saito, Yoshihito| Yamamoto, Michinori| Ofuji, Tadashi|
抄録 <p>Purification of antilymphocyte antibody (ALA) from patients with systemic lupus erythematosus (SLE) was achieved by immunoabsorption and elution. Human tonsil cells or thymocytes were used as absorbents. Complement dependent microcytotoxicity tests showed that, in comparison to the parent sera, the eluate from tonsil cells was eight times, and that from thymocytes four times, more active. Antinuclear activity was eliminated by elution. The ALA was almost entirely IgM, IgG being involved in only a few cases. IgA lacked cytotoxic activity. ALA was directed at both T- and B-cell surface determinants, which suggests that, in SLE, it has a heterogeneous biological composition.</p>
キーワード antilymphocyte antibody systemic lupus erythematosus purification
Amo Type Article
発行日 1979-08
出版物タイトル Acta Medica Okayama
33巻
4号
出版者 Okayama University Medical School
開始ページ 259
終了ページ 267
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 91309
JaLCDOI 10.18926/AMO/32041
フルテキストURL fulltext.pdf
著者 Yokoyama, Hisamitsu| Yumane, Yukio| Takahara, Jiro| Yoshinouchi, Takeo| Ofuji, Tadashi|
抄録 <p>An unusual case of orbital tumor with high renin content and severe hypertension is described. The patient was a 15-year-old girl with juvenile hypertension (200-140 mmHg) associated with right exophthalmos and hypokalemia. The patient showed extremely high levels of plasma renin activity and plasma aldosterone concentration. No difference was present in plasma renin activity from either side of the renal veins. Preoperatively, hypertension responded to treatment with spironolactone. The tumor could not be completely removed because of intracranial metastasis and infiltration, and the hyperreninemia and secondary hyperaldosteronism persisted. The renin content in the orbital tissue was 1,403-2,225 ng/angiotensin I generated/h/g wet weight of tissue. The postmortem histopathologic diagnosis was orbital hemangiopericytoma. This is the first case of extrarenal (ectopic) renin-secreting (or -producing) hemangiopericytoma of the orbital origin. Furthermore this case is worthy of note in the point of view of the presence of the extrarenal renin-angiotensin system, particularly in the brain.</p>
キーワード renin producing tumor hemangiopericytoma juvenile hypertension hypokalemia orbital tumor
Amo Type Brief Note
発行日 1979-08
出版物タイトル Acta Medica Okayama
33巻
4号
出版者 Okayama University Medical School
開始ページ 315
終了ページ 322
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 158952
NAID 120002311859
JaLCDOI 10.18926/AMO/32052
フルテキストURL fulltext.pdf
著者 Makino, Hirofumi| Ota, Zensuke| Takaya, Yasumasa| Kida, Keiko| Miyoshi, Akira| Hiramatsu, Makoto| Takahashi, Kayo| Ofuji, Tadashi|
抄録 <p>The tubular basement membrane (TBM) (i.e. tubular basal lamina) of rat kidney was shown to be a fine meshwork by electron microscopy after negative staining. Strands of the meshwork formed a regular three dimensional lattice work. The pores of the meshwork were polygonal. There were two main pore sizes: one approximately 30 A in diameter, the other 42--60 A. In view of our previous observation that glomerular and alveolar basement membranes were made up fine meshwork, it is quite possible that the basement membranes of other organs are also made up such fine meshwork.</p>
キーワード renal tubular basement membrane mesh work structure pore negative staining electron micro scopy
Amo Type Brief Note
発行日 1979-04
出版物タイトル Acta Medica Okayama
33巻
2号
出版者 Okayama University Medical School
開始ページ 133
終了ページ 136
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 89787
NAID 120002312032
JaLCDOI 10.18926/AMO/32053
フルテキストURL fulltext.pdf
著者 Hashimoto, Kozo| Yunoki, Sho| Hosogi, Hidemi| Takahara, Jiro| Ofuji, Tadashi|
抄録 <p>Biologically active peptides and neurotransmitter substances were added to anterior pituitary cell cultures to examine the presence of corticotropin releasing factor (CRF)-like activity. Hypothalamic extract (HE) induced significant dose-related increase of ACTH, and the lowest effective dose was 0.01 HE/ml. Other tested substances including luteinizing hormone-releasing hormone, thyrotropin releasing hormone, melanocyte stimulating hormone release inhibiting factor, somatostatin, substance P, neurotensin, beta-endorphin. leu-enkephalin, met-enkephalin, bradykinin, norepinephrine, dopamine, serotonin, acetylcholine, histamine, gamma-amino butyric acid or gamma-hydroxy butyric acid showed no CRF-like activity. Relatively high doses of lysine vasopressin, arginine vasopressin and angiotensin II increased the release of ACTH in pituitary cell cultures, but the maximal ACTH response was markedly less than with HE. These results indicate that cultured anterior pituitary cells are sensitive and fairly specific in detecting CRF(s) comparing with other detecting procedures.</p>
キーワード pituitary cell cultures corticotropin releasing factor ACTH neuropeptides neurotransmitter substances
Amo Type Article
発行日 1979-04
出版物タイトル Acta Medica Okayama
33巻
2号
出版者 Okayama University Medical School
開始ページ 81
終了ページ 90
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 38634
NAID 120002311394
JaLCDOI 10.18926/AMO/32075
フルテキストURL fulltext.pdf
著者 Mitsunaga, Mikio| Hasegawa, Kan| Nakagawa, Osamu| Nakashima, Yusaku| Miyoshi, Masanori| Suzuki, Shinya| Ofuji, Tadashi|
抄録 <p>A case of a 40-year-old woman who was suffering from painless thyroiditis with recurrent transient thyrotoxicosis is reported. Acute exacerbations occurred four times during the past ten years, two after delivery and two after catching a cold. Serum thyroid hormones increased, though radioiodine uptake by the thyroid was very low and no inflammatory signs were observed. The histological findings of the thyroid were of atypical thyroiditis and not consistent with either chronic lymphocytic thyroiditis or subacute thyroiditis. Tanned sheep red cell hemagglutination titers for anti-thyroglobulin antibodies (TRC) and for anti-microsomal antibodies (MHA) were negative or low. The disease seems to be rare and the pathophysiology and etiology are discussed.</p>
キーワード recurrent transient thyrotoxicosis painless thyroiditis hyper-thyroiditis subacute thyroiditis chronic lymphocytic thyroiditis
Amo Type Article
発行日 1979-02
出版物タイトル Acta Medica Okayama
33巻
1号
出版者 Okayama University Medical School
開始ページ 43
終了ページ 51
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 155981
著者 Ofuji, Tadashi|
発行日 1964-04
出版物タイトル Acta Medicinae Okayama
18巻
2号
資料タイプ 学術雑誌論文
著者 Hiraki, Kiyoshi| Ofuji, Tadashi| Sunami, Hiroshi| Ota, Zensuke| Kitajima, Koichi| Shinagawa, Koji| Kibata, Masayoshi| Miyoshi, Isao| Hanazawa, Atsumasa|
発行日 1963-02
出版物タイトル Acta Medicinae Okayama
17巻
1号
資料タイプ 学術雑誌論文
著者 Okada, Soji| Kawanishi, Koichi| Ofuji, Tadashi|
発行日 1974-08
出版物タイトル Acta Medica Okayama
28巻
4号
資料タイプ 学術雑誌論文
著者 Kawanishi, Koichi| Sato, Keiichiro| Ofuji, Tadashi| Ogawa, Katsuo|
発行日 1974-12
出版物タイトル Acta Medica Okayama
28巻
6号
資料タイプ 学術雑誌論文
著者 Nishiya, Koji| Yamana, Seizo| Yano, Keisuke| Ensako, Katuhide| Fujiwara, Tadaaki| Ofuji, Tadashi|
発行日 1974-10
出版物タイトル Acta Medica Okayama
28巻
5号
資料タイプ 学術雑誌論文
著者 Okada, Soji| Kawanishi, Koichi| Ofuji, Tadashi|
発行日 1974-10
出版物タイトル Acta Medica Okayama
28巻
5号
資料タイプ 学術雑誌論文