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ID 31042
フルテキストURL
著者
Kawanishi, Koichi Okayama University
Goto, Akio Okayama University
Ishida, Toshihiko Okayama University
Kawamura, Ko Okayama University
Nishina, Yoshiaki Okayama University
Machida, Shuji Okayama University
Yamamoto, Shinro Okayama University
Ofuji, Tadashi Okayama University
抄録

Effects of synthetic neurotensin on the endocrine pancreas were studied in nine normal and six hypophysectomized (10th to 14th day post-hypophysectomy) dogs. Synthetic neurotensin was administered into the superior pancreaticoduodenal artery, and plasma insulin and glucagon concentrations were measured radioimmunologically. In normal dogs, ten microgram/kg neurotensin administration brought about a mild hyperglycemic response and sharp and rapid increase of plasma insulin and glucagon concentrations in the superior pancreaticoduodenal vein. A biphasic insulin response was noted in the pancreatic vein. The results suggest that a large dose of neurotensin acts directly on the endocrine pancreas causing secretion of these hormones. In hypophysectomized dogs, basal levels of plasma insulin and glucagon were decreased and neurotensin had little effect on the endocrine pancreas even with the administration of a large dose.

キーワード
neurotensin
insulin
glucagon
hypophysectomy
発行日
1978-08
出版物タイトル
Acta Medica Okayama
32巻
4号
出版者
Okayama University Medical School
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Amo Type
Article
Submission Path
amo/vol32/iss4/6