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ID 56075
JaLCDOI
フルテキストURL
Thumnail 72_3_289.pdf 3.16 MB
著者
Kitajima, Kazuhiro Division of Nuclear Medicine and PET Center, Hyogo College of Medicine
Yamamoto, Shingo Department of Urology, Hyogo College of Medicine
Odawara, Soichi Division of Nuclear Medicine and PET Center, Hyogo College of Medicine
Kobayashi, Kaoru Department of Radiology, Hyogo College of Medicine
Fujiwara, Masayuki Department of Radiology, Hyogo College of Medicine
Kamikonya, Norihiko Department of Radiology, Hyogo College of Medicine
Fukushima, Kazuhito Department of Nuclear Medicine, University Hospital Wuerzburg
Nakanishi, Yukako Department of Urology, Hyogo College of Medicine
Hashimoto, Takahiko Department of Urology, Hyogo College of Medicine
Yamada, Yusuke Department of Urology, Hyogo College of Medicine
Suzuki, Toru Department of Urology, Hyogo College of Medicine
Kanematsu, Akihiro Department of Urology, Hyogo College of Medicine
Nojima, Michio Department of Urology, Hyogo College of Medicine
Yamakado, Koichiro Department of Radiology, Hyogo College of Medicine
抄録
We compared 11C-choline and FDG PET/CT scan findings for the staging and restaging of prostate cancer. Twenty Japanese prostate cancer patients underwent 11C-choline and FDG PET/CT before (n=5) or after (n=15) treatment. Using a five-point scale, we compared these scanning modalities regarding patient- and lesion-based diagnostic performance for local recurrence, untreated primary tumor, and lymph node and bony metastases. Of the 20 patients, documented local lesions, and node and bony metastases were present in 11 (55.0%), 9 (45.0%), and 13 (65.0%), respectively. The patient-based sensitivity/specificity/accuracy/area under the receiver-operating-characteristic curve (AUC) values for 11C-choline-PET/CT for diagnosing local lesions were 90.9% /100%/ 95.0% / 1.0, whereas those for FDG-PET/CT were 45.5% /100%/ 75.0% / 0.773. Those for 11C-choline-PET/CT for node metastasis were 88.9% /100%/ 95.0% / 0.944, and those for FDG-PET/CT were 44.4%/100%/75.0%/0.722. Those for 11C-choline-PET/CT for bone metastasis were 84.6%/100%/90.0%/0.951, and those for FDG-PET/CT were 76.9% /100%/ 85.0% / 0.962. The AUCs for local lesion and node metastasis differed significantly (p=0.0039, p=0.011, respectively). The lesion-based detection rates of 11C-choline compared to FDG PET/CT for local lesion, and node and bone metastases were 91.7% vs. 41.7%, 92.0% vs. 32.0%, and 94.8% vs. 83.0% (p=0.041, p=0.0030, p<0.0001), respectively. 11C-choline-PET/CT is more useful for the staging and restaging of prostate cancer than FDG-PET/CT in Japanese men.
キーワード
prostate cancer
PET
choline
FDG
Japanese
Amo Type
Original Article
発行日
2018-06
出版物タイトル
Acta Medica Okayama
72巻
3号
出版者
Okayama University Medical School
開始ページ
289
終了ページ
296
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
CopyrightⒸ 2018 by Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID