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ID 44291
フルテキストURL
Thumnail 53_2527.pdf 3.44 MB
タイトル(別表記)
Studies of Acetylcholine and Anticholinesterase The second Report. About the concentration-action curve of A. Ch.
著者
奥田 一誠 岡山醫科大學生理學教室
抄録
The writer cxperimented the relation between the concentration and the action of A. Ch. on the eserinised rectus abdominis of frog, and the action of A. Ch. and atropine on the same, when both are present. The results are as follows. 1) The relation between the concentration of A. Ch. and the action produced can be expressed by the formula Kx = y/(100-y) where x concentration of A. Ch., y action produced, expressed as percent to the maximal possible action, and K constant. This relation suggests that a reversible monomolecular reaction occurs between A. Ch. and receptors either in the cell or on its surface. 2) This relation is not influenced by atropine. 3) The relation between the molar concentration of A. Ch. and Atropine on the eserinised abdominal rectus muscle of the frog is as follows. Concentration A. Ch. / (Concentration Atropine)(1.5) = Constant This formula shows that 1.5 molecules of atropine combine each receptor. After all the writer's results are similary as Clark's results. That is to say, cholinesterase has no effect upon the shape of the concentration-action curve.
発行日
1941-12-31
出版物タイトル
岡山医学会雑誌
53巻
12号
出版者
岡山医学会
開始ページ
2527
終了ページ
2533
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1889/53/12/53_12_2527/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
Copyright© 岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma