JaLCDOI 10.18926/AMO/32092
フルテキストURL fulltext.pdf
著者 Kitamura, Yoshihisa| Araki, Hiroaki| Nagatani, Tadashi| Takao, Katsuyuki| Shibata, Kazuhiko| Gomita, Yutaka|
抄録 <p>We studied the influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. Both single and chronic administration of imipramine potently shortened immobility in naive rats during forced-swim testing. However, chronic, 14-day forced-swim stress testing blocked the immobility-decreasing effect induced by a single administration of imipramine. When imipramine was administered for 14 days concurrently with forced-swim stress testing, immobility was shortened significantly. From the viewpoint of imipramine's effect, these findings suggest that chronic forced-swim stress testing in rats may be an effective animal model for depression.</p>
キーワード stress depression imipramine forced-swim test animal model
Amo Type Article
発行日 2004-12
出版物タイトル Acta Medica Okayama
58巻
6号
出版者 Okayama University Medical School
開始ページ 271
終了ページ 274
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 15762295
Web of Sience KeyUT 000225959100003