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ID 32030
JaLCDOI
フルテキストURL
Thumnail fulltext.pdf 1.06 MB
著者
Bagum, Mossa Arujuma Kagawa Medical University
Miyamoto, Osamu Kagawa Medical University
Masada, Tetsuya Kagawa Medical University
Nagahata, Shun-ichirou Kagawa Medical University
Toyoshima, Tetsuhiko Kagawa Medical University
抄録

The implication of low affinity nerve growth factor receptor (p75NGFR), which is believed to play a pro-apoptotic role, in delayed neuronal death (DND) after ischemia in the gerbil hippocampus was investigated. Immunohistochemistry and Western blot analysis revealed that the presence of p75 NGFR immunoreactivity (IR) was negligible in the hippocampus of the sham control gerbil but appeared clearly in CA1 neurons 3 and 4 days after 5-min transient ischemia. Terminal deoxynucleotidyl transferase-mediated UTP nick end labeling (TUNEL)

positive nuclei appeared when the level of p75NGFR IR increased. Furthermore, almost all TUNEL-positive CA1 neurons also costained for p75NGFR. These results suggest that p75NGFR contributes to DND after ischemia by an apoptotic mechanism.

キーワード
p75NGFR
apoptosis
delayed neuronal death
ischemia
gerbil
Amo Type
Article
発行日
2001-02
出版物タイトル
Acta Medica Okayama
55巻
1号
出版者
Okayama University Medical School
開始ページ
19
終了ページ
24
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT