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ID 30561
JaLCDOI
フルテキストURL
著者
Miyoshi, Masanori Okayama University
Nakashima, Yusaku Okayama University
Hirakawa, Shuzo Okayama University
Mitsunaga, Mikio Okayama University
Nakagawa, Osamu Okayama University
Miura, Hiroshi Okayama University
Suzuki, Shinya Okayama University
Ofuji, Tadashi Okayama University
抄録

Function of pituitary-thyroid axis was studied in rats with experimentally induced thyroiditisWistar strain female rats were immunized with homologous thyroid extract in Freund's complete adjuvant and with simultaneous intradermal injection of pertussis vaccine concentrate. They received booster shots at the first and third week after the initial immunization. Serum thyroid hormones and TSH were measured just before, and at weekly intervals after, the initial immunization. Histological examination of the thyroid gland at the second week after immunization showed slight infiltration of macrophages in the thyroid follicles. From the third to the fourth week, massive lymphoid cell infiltration and destruction of follicular architecture developed in all immunized rats. Serum R3 levels slightly decreased during the second week, increased transiently during the third week, then decreased again thereafter. Serum T4 levels decreased slightly durinf the fourth week. Serum TSH levels were not elevated significantly during the third week, but the response to TRH was significantly increased at this time. Basal TSH levels were increased during the fourth week. The TRH test was a sensitive method capable of detecting minimal failure of thyroid function undetected by other routine measuremens of thyroid hormones and TSH.

キーワード
thyroid function
thyrotropin (TSH)
experimental thyroiditis
thyroid hormones.
Amo Type
Article
発行日
1980-02
出版物タイトル
Acta Medica Okayama
34巻
1号
出版者
Okayama University Medical School
開始ページ
11
終了ページ
17
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT