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ID 30400
JaLCDOI
フルテキストURL
著者
Watanabe, Hitoshi Okayama University
Ogura, Toshio Okayama University
Hosoya, Masaharu Okayama University
Nishida, Norikazu Okayama University
Ota, Zensuke Okayama University
抄録

<p>To assess the role of the kidney dopamine system on the diuretic state induced by angiotensin-converting enzyme (ACE) inhibitors, we examined the changes in urinary excretion and plasma level of dopamine, and kidney dopamine receptors in spontaneously hypertensive rats (SHR) treated with cilazapril, an ACE inhibitor. We administered cilazapril 10 mg/kg orally to 13-week-old SHR daily for 21 days (CILAZA group). Systolic blood pressure was significantly decreased in the CILAZA group on Day 6 compared with that in vehicle-treated SHR (control group). The urine volume was three- to fivefold higher in the CILAZA group, and total urinary dopamine secretion was also increased compared with the control group. There was no significant difference in affinity and number of kidney dopamine receptors between the CILAZA and the control groups. In conclusion, the diuretic effect caused by cilazapril is partly mediated by inhibition of the water reabsorption via the increase of dopamine production in the kidney.</p>

キーワード
dopamine
ACE inhibitor
cilazapril
SHR
kidney
Amo Type
Article
発行日
1995-10
出版物タイトル
Acta Medica Okayama
49巻
5号
出版者
Okayama University Medical School
開始ページ
247
終了ページ
252
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT