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ID 16155
Eprint ID
16155
フルテキストURL
Thumnail 97_341.pdf 345 KB
タイトル(別表記)
Epldemiological Studies of Chlordane for Termite Prevention Part 3. Effect of chlordane on oxidative phosphorylation in rat liver mitochondria
著者
野口 信行 岡山大学医学部公衆衛生学教室
抄録
In order to clarify the cytotoxicity of chlordane (industrial product as insecticide), the effect on oxidative phosphorylation in rat liver mitochondria was studied. The respiration rate. RCI and ADP/O ratio were inhibited by chlordane related compounds, and the degree of inhibition was in the descending order of trans-chlordane, cis-chlordane, heptachlor and heptachlor epoxide. Of the indexes indicating various respiratory activities, state 3 respiration was the most sensitively inhibited by these compounds, suggesting their energy transfer inhibition. However, electron transport was also inhibited by high concentrations of chlordane constituents. The inhibitory effect of the chlordane constituents on respiratory activity varied depending on the species of respiratory substrate, suggesting site specificity of these compounds. Trans-chlordane, cis-chlordane and heptachlor stimulated Mg(2+) ATPase activity and inhibited DNP-stimulated ATPase activity. Heptachlorepoxide, a metabolic product of heptachlor, has less effect on mitochondria than heptachlor.
キーワード
クロルデン
ミトコンドリア
酸化的リン酸化
発行日
1985-04-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
97巻
3-4号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
341
終了ページ
349
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/97/3-4/97_3-4_341/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma