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ID 16154
Eprint ID
16154
フルテキストURL
Thumnail 97_327.pdf 1.2 MB
タイトル(別表記)
Epidemiological studies of chlordane for termite prevention Part 2. Metabolism of chlordane in exposed rats
著者
野口 信行 岡山大学医学部公衆衛生学教室
抄録
I exposed rats to chlordane (industrial product) and measured the concentration of chlordane in various tissues of rats over time. Exposure to chlordane for 3.5 hours appoximated the exposure to chlordane in a house a hundred days after treatment for termites. However, chlordane and metabolites were detected in all the tissues of rats. The concentration of chlordane in various tissues showed highest level one hour after exposure. After that, heptachlor, γ-chlordane, trans-chlordane and cis-chlordane were excreted fast, while trans-noachlor and cis-nonachlor were excreted extremely slowly. The metabolites of chlordane (heptachlorepoxide and oxichlordane) showed the highest level one after exposure in the various tissues, and after that they were excreted slowly. Chlordane had the highest level in the adipose tissue and the second highest level in the liver, kidney, lung, pectoral muscle and heart. In the spleen and brain it showed a relatively low level. The lowest level was in the blood. As for Biological Harf Life (B.H.L.), the number of days in the secondary excretion in the adipose tissue of chlordane excreted late was as follows: trans-nonachlor 38.5 days, cis-nonachlor 16.5 days, and metabolites 16.9 days. It is suggested that the chronic toxicity of trans-nonachlor, cis-nonachlor and metabolites should be investigated in future.
キーワード
クロルデン
暴露ラット
生体内運命
生物学的半減期
発行日
1985-04-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
97巻
3-4号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
327
終了ページ
339
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/97/3-4/97_3-4_327/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma