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ID 32891
JaLCDOI
フルテキストURL
著者
Yuasa, Ichiro Okayama University
Tsukuda, Kazunori Okayama University
Hirai, Ryuji Okayama University
Ota, Tetsuya Okayama University
Murakami, Masakazu Okayama University
Naito, Minoru Okayama University
Doihara, Hiroyoshi Okayama University Kaken ID researchmap
Date, Hiroshi Okayama University
Shimizu, Nobuyoshi Okayama University
抄録

Resection is the only curative treatment for liver metastasis of colorectal cancers. Despite the supreme regenerative potential of the liver, major hepatectomy sometimes leads to liver failure, and the limitation of resectable liver volumes makes advanced tumors inoperable. This study was attempted to promote liver regeneration using hepatocyte growth factor (HGF) gene transfection by venous-administered adenovirus and to improve the survival of rats after massive hepatectomy. The adenovirus that encodes HGF was administered to rats before 85%-hepatectomy. The administration of HGF gene improved the survival of rats after massive hepatectomy, while the administration of control adenovirus deteriorated their survival. Gene transfection of HGF showed up-regulation of serum HGF, stimulation of hepatocellular proliferation and rapid liver regeneration. Moreover, HGF administration reduced apoptosis of hepatocytes. The administration of HGF gene prevented liver dysfunction after major hepatectomy and may be a new assist for surgery.

キーワード
gene therapy
hepatectomy
HGF
adenoviral vector
Amo Type
Original Article
発行日
2007-04
出版物タイトル
Acta Medica Okayama
61巻
2号
出版者
Okayama University Medical School
開始ページ
81
終了ページ
88
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT