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ID 34207
フルテキストURL
著者
Ali, Hamed I.. Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Tomita, Keiichiro Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
Akaho, Eiichi Faculty of Pharmaceutical Sciences, High Technology Research Center (Life Science Center), and Center for Area Research and Development, Kobe Gakuin University
Kambara, Hiroto Faculty of Pharmaceutical Sciences, High Technology Research Center (Life Science Center), and Center for Area Research and Development, Kobe Gakuin University
Miura, Shinji Biology Laboratory, Research and Development Division, Yamasa Shoyu Co.
Hayakawa, Hiroyuki Biology Laboratory, Research and Development Division, Yamasa Shoyu Co.
Ashida, Noriyuki Biology Laboratory, Research and Development Division, Yamasa Shoyu Co.
Kawashima, Yutaka Medicinal Research Laboratories, Taisho Pharmaceutical Co.
Yamagishi, Takehiro Medicinal Research Laboratories, Taisho Pharmaceutical Co.
Ikeya, Hisao Medicinal Research Laboratories, Taisho Pharmaceutical Co.
Yoneda, Fumio Faculty of Pharmaceutical Sciences, Kyoto University
Nagamatsu, Tomohisa Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
抄録
Novel 2-deoxo-2-phenyl-5-deazaflavins and 2-deoxo-2-phenylflavin-5-oxides were prepared as a new class of antitumor agents and showed significant antitumor activities against NCI-H 460, HCT 116, A 431, CCRF-HSB-2, and KB cell lines. In vivo investigation, 2-deoxo-10-methyl-2-phenyl-5-deazaflavin exhibited the effective antitumor activity against A 431 human adenocarcinoma cells transplanted subcutaneously into nude mouse. Furthermore, AutoDock study has been done by binding of the flavin analogs into PTK pp60(c-src), where a good correlation between their IC50 and AutoDock binding free energy was exhibited. In particular, 2-deoxo-2-phenylflavin-5-oxides exhibited the highest potential binding affinity within the binding pocket of PTK.
キーワード
antitumor activity
Flavin analog
AutoDock
protein tyrosine kinase
備考
Published with permission from the copyright holder.
This is a author's copy,as published in Bioorganic & Medicinal Chemistry , 2007 Vol.15 Issue.1 pp.242-256
Publisher URL: http://dx.doi.org/10.1016/j.bmc.2006.09.063
Direct access to Thomson Web of Science record
Copyright © 2007 by Elsevier Ltd.
発行日
2007-01-01
出版物タイトル
Bioorganic & Medicinal Chemistry
15巻
1号
出版者
Pergamon-Elsevier Science Ltd.
開始ページ
242
終了ページ
256
ISSN
0968-0896
NCID
AA10938083
資料タイプ
学術雑誌論文
言語
English
著作権者
Elsevier Ltd.
論文のバージョン
author
査読
有り
DOI
PubMed ID
Web of Sience KeyUT
Submission Path
organic_chemistry/11