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ID 52036
フルテキストURL
著者
Maki, Yuho Okayama Univ Hosp, Dept Thorac Surg
Soh, Junichi Okayama Univ Hosp, Dept Thorac Surg
Ichimura, Kouichi Okayama Univ Hosp, Dept Pathol
Shien, Kazuhiko Okayama Univ Hosp, Dept Thorac Surg
Furukawa, Masashi Okayama Univ Hosp, Dept Thorac Surg
Muraoka, Takayuki Okayama Univ Hosp, Dept Thorac Surg
Tanaka, Norimitsu Okayama Univ Hosp, Dept Thorac Surg
Ueno, Tsuyoshi Okayama Univ Hosp, Dept Thorac Surg
Yamamoto, Hiromasa Okayama Univ Hosp, Dept Thorac Surg
Asano, Hiroaki Okayama Univ Hosp, Dept Thorac Surg
Tsukuda, Kazunori Okayama Univ Hosp, Dept Thorac Surg
Toyooka, Shinichi Okayama Univ Hosp, Dept Thorac Surg
Miyoshi, Shinichiro Okayama Univ Hosp, Dept Thorac Surg
抄録
High expression levels of glucose transporter isoform 1 (GLUT1) and Ki-67 are reportedly associated with malignancy-related clinicopathological factors in malignant tumors. Recently, a new histological IASLC/ATS/ERS classification for lung adenocarcinoma was proposed. In this study, we investigated the clinicopathological impact of GLUT1 and Ki-67 expression on early-stage lung adenocarcinoma classified according to the IASLC/ATS/ERS classification. One hundred and five patients with completely resected stage IA lung adenocarcinoma were retrospectively classified into two groups, a 'non-invasive type' (n=31) or an 'invasive type' (n=74), based on the IASLC/ATS/ERS classification. GLUT1 and Ki-67 expression status was evaluated using immunohistochemistry. The epidermal growth factor receptor (EGFR) and KRAS mutation status was determined using PCR-based assays. Positive GLUT1 and Ki-67 expression and EGFR and KRAS mutations were detected in 28 (27%), 33 (31%), 51 (49%) and 5 (8%) cases, respectively. Positive GLUT1 expression was significantly associated with a wild-type EGFR and mutant KRAS status. A multivariate analysis revealed that positive GLUT1 expression was independently associated with the 'invasive type'. In multivariate analyses for overall survival (OS) and disease-free survival (DFS), positive Ki-67 and GLUT1 expression was the only independent factor for a poor OS (P=0.012) and DFS (P=0.040), respectively. In addition, when stratified according to the GLUT1 and Ki-67 status, double-positive cases had the poorest DFS and OS times, compared with the other categories. Positive GLUT1 expression is associated with the invasive character of early-stage lung adenocarcinoma and with early disease relapse. Our results strongly suggest that GLUT1 and Ki-67 play important roles in acquiring biological malignant potential in early-stage lung adenocarcinoma.
キーワード
early-stage lung adenocarcinoma
glucose transporter isoform 1
Ki-67
発行日
2013-01
出版物タイトル
Oncology Reports
29巻
1号
開始ページ
133
終了ページ
140
ISSN
1021-335X
資料タイプ
学術雑誌論文
オフィシャル URL
http://dx.doi.org/10.3892/or.2012.2087
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/51970
言語
English
論文のバージョン
publisher
査読
有り
DOI
Web of Sience KeyUT