JaLCDOI 10.18926/AMO/31939
フルテキストURL fulltext.pdf
著者 Sakagami, Kenichi| Takeuchi, Hitoshi| Tsuboi, Katsutoshi| Matsumoto, Takamasa| Tanaka, Kohtaro| Ohsaki, Toshihide| Horimi, Tadashi| Fuchimoto, Sadanori| Orita, Kunzo|
抄録 <p>The survival rate of 19 patients who underwent living-related kidney transplantation after donor-specific blood transfusions (DST) was compared with that of 32 historical controls receiving transplants without DST. The graft survival rate of the DST group was 82% after two and three years. The graft survival rate of the DST group was significantly better than the 53% rate after two years obtained with the 32 historical controls (p less than 0.05). We tested sera from 16 DST-treated recipients to study the beneficial effect of DST on kidney allograft survival using the mixed lymphocyte culture (MLC) serum inhibition test. The results demonstrated that MLC inhibitory factors were induced in the serum of the recipient after completion of DST. This inhibition of MLC was observed by treatment of responder lymphocytes with serum obtained three weeks after DST plus rabbit complement. The inhibitory effect was also specific for responder cells in anti-donor MLC. Regarding the correlation with rejection episodes, these MLC inhibitory factors were often observed in the non-rejection group (p less than 0.05). The data suggest that such factors may be anti-idiotypic antibodies and be associated with prolonged graft survival.</p>
キーワード kidney transplantation donor-specific blood transfusion (DST) MLC inhibitory factors anti-idiotypic antibody.
Amo Type Article
発行日 1986-02
出版物タイトル Acta Medica Okayama
出版者 Okayama University Medical School
開始ページ 39
終了ページ 43
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 2938423
Web of Science KeyUT A1986A190200006