JaLCDOI 10.18926/AMO/32647
フルテキストURL fulltext.pdf
著者 Yamamoto, Hideki| Ishii, Kunihiko| Meguro, Tadamichi| Taketa, Kazuhisa| Ogata, Masana|
抄録 <p>In order to elucidate the role of erythrocyte catalase in the accumulation of mercury in erythrocytes, labeled erythrocytes and plasma were prepared by exposing normal and acatalasemic mice to radioactive mercury vapor (203Hg0: 6.8mg/m3) for 30 min. Labeled erythrocytes (or plasma) were mixed with unlabeled plasma (or erythrocytes) of normal or acatalasemic mice and incubated at 0 degrees C for 1 h. After incubation, the radioactivity of mercury in the erythrocytes and the plasma was measured by a gammascintillation counter. When labeled erythrocytes were incubated with unlabeled plasma, the ratio of mercury transferred from acatalasemic erythrocytes to normal plasma (11.6%) or to acatalasemic plasma (13.3%) were significantly higher than that from normal erythrocytes to normal plasma (1.8%) or to acatalasemic plasma (2.2%). When labeled normal (or acatalasemic) plasma was incubated with unlabeled normal or acatalasemic erythrocytes, the uptake of mercury by acatalasemic erythrocytes from normal plasma was 2.0%, and 1.2% from acatalasemic plasma, which tended to be lower than that by normal erythrocytes from normal plasma (3.4%) or from acatalasemic plasma (2.2%). The results indicated impaired accumulation of mercury in acatalasemic erythrocytes, suggesting the importance of catalase in taking up mercury in erythrocytes and protecting other organs from toxic effects of metallic mercury.</p>
キーワード mercury catalase acatalasemia erythrocytes biological monitoring
Amo Type Article
発行日 1992-04
出版物タイトル Acta Medica Okayama
46巻
2号
出版者 Okayama University Medical School
開始ページ 67
終了ページ 73
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 1575060
Web of Science KeyUT A1992HR48400002
JaLCDOI 10.18926/AMO/32441
フルテキストURL fulltext.pdf
著者 Meguro, Tadamichi| Ogata, Masana|
抄録 <p>Maximal expiratory volume-time and flow-volume (MEVT and MEFV) curves were constructed from the measurements of young male nonsmoking, mild and moderate asthmatic patients (mean age, 29.7 yrs.). Eleven parameters of the pulmonary function tests, two MEVT, six MEFV, and three mean time constant (MTC) parameters, were calculated from the curves. These parameters were used in 15 analyses through the all possible selection procedure (APAP) discriminating between mild and moderate asthmatics. The probability of misclassification was computed with each of the eleven parameters, and all eleven probabilities thus obtained were compared with each other. This procedure showed us that the probability of misclassification ranged from 30.83% to 45.40% and that the most useful parameter was MTC50-25. The probability of misclassification computed using all eleven parameters (total parameter group) was 15.90%. The discriminant analysis indicated that the flow-volume patterns varied according the severity of bronchial asthma, thus, the flow-volume curve was considered to be important in analyzing the severity of bronchial asthma.</p>
キーワード discriminant analysis the volume-time and flow-volume curve the all possible selection procedure (APSP) asthmatic severity the probability of misclassification
Amo Type Article
発行日 1983-02
出版物タイトル Acta Medica Okayama
37巻
1号
出版者 Okayama University Medical School
開始ページ 51
終了ページ 58
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6846052
Web of Sience KeyUT A1983QD83600006
JaLCDOI 10.18926/AMO/32416
フルテキストURL fulltext.pdf
著者 Meguro, Tadamichi| Ogata, Masana| Nishioka, Keiko| Yamanaka, Mayu| Ogura, Yoshiro|
抄録 <p>We considered upper and lower airway allergies as different phases of airway allergy and MEFV patterns to vary according to the intensity of airway obstruction in maximal expiratory flow-volume and volume-time tests on fourteen patients with nasal allergy, two with allergic bronchitis, two with bronchial asthma, and sixteen nonsmoking healthy subjects. In nasal allergy, flow changes during high lung volumes were different from those in allergic bronchitis and bronchial asthma, and MEFV patterns in nasal allergy were more widely varied than those in allergic bronchitis and bronchial asthma. We classified MEFV patterns into five ones.</p>
キーワード MEFV pattern airway allergy nasal allergy bronchial asthma type of MEFV pattern
Amo Type Brief Note
発行日 1983-04
出版物タイトル Acta Medica Okayama
37巻
2号
出版者 Okayama University Medical School
開始ページ 163
終了ページ 166
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 6869066
Web of Science KeyUT A1983QN63900010
JaLCDOI 10.18926/AMO/32219
フルテキストURL fulltext.pdf
著者 Meguro, Tadamichi| Ogata, Masana|
抄録 <p>Pulmonary function tests were performed on 252 healthy young subjects free from respiratory and allergic symptoms, and 80 young subjects with past history of nasal allergy (PNA) and 10 subjects with past history of bronchial asthma (PBA). All the subjects were non-smokers. Maximal expiratory flow-volume (MEFV) curves were visually classified into five types (A-E). The percent distribution of type A in healthy subjects was significantly higher than in the PNA group, while the total sum of percentage of types B, C, and D in the PNA group was significantly higher than in the healthy subjects. The percent distribution of type E in the PNA group was similar to that in the healthy subjects. The percent distribution of MEFV types were significantly different between healthy males and healthy females. The percent distribution of types A, B and E were the highest in healthy subjects, PNA and PBA groups, respectively. Conclusively, the difference in the percent distributions of MEFV types was recognized among healthy subjects, PNA and PBA groups.</p>
キーワード maximal expiratory flow-volme type non-smoking bronchial asthma nasal allergy
Amo Type Article
発行日 1991-02
出版物タイトル Acta Medica Okayama
45巻
1号
出版者 Okayama University Medical School
開始ページ 29
終了ページ 35
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 2063693
Web of Sience KeyUT A1991FA75000004
JaLCDOI 10.18926/AMO/32048
フルテキストURL fulltext.pdf
著者 Ogata, Masana| Norichika, Kazuko| Shimada, Yoshihiro| Meguro, Tadamichi|
抄録 <p>Differences in urinary excretion of trichloroethylene were studied in rabbits, rats and mice. Trichloretylene (1 m mole/kg) was injected intra-peritoneally, then urinary trichloroacetic acid and trichloroethanol glucuronide were measured. The results were: 1. The ratio of total excretion of trichloroethylene metabolites to the administered trichloroethylene decreased in the order of mice, rats and rabbits. 2. The ratio of total trichloroethanol to trichloroacetic acid in urine decreased in the order of rabbits (69.2), mice (12.8) and rats (2.3). The high ratio in rabbits was due to the extremely small amount of trichloroacetic acid in the urine. 3. Differences in these two urinary metabolites in the three kinds of animals and in human subjects were discussed.</p>
キーワード trichlorethylene species-difference trichloroethanol trichloroacetic acid urinary metabolites
Amo Type Article
発行日 1979-12
出版物タイトル Acta Medica Okayama
33巻
6号
出版者 Okayama University Medical School
開始ページ 415
終了ページ 421
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 161467
NAID 120002312109
JaLCDOI 10.18926/AMO/31905
フルテキストURL fulltext.pdf
著者 Meguro, Tadamichi|
抄録 <p>Maximal expiratory volume-time and flow-volume (MEVT and MEFV) curves were drawn for young male nonsmoking healthy adults and for young male nonsmoking asthmatic patients. Eleven parameters, two MEVT (%FVC and FEV1.0%), six MEFV (PFR, V75, V50, V25, V10 and V50/V25), and three MTC parameters (MTC75-50, MTC50-25 and MTC25-RV) were used for the multivariate analysis. The multivariate analysis in this study consisted of correlation coefficient matrix computation, the test for mean values in the multivariates, and the linear discriminant analysis using the all possible selection procedure (APSP). Correlation coefficients among flow rate parameters and flow rate related parameters in high lung volumes were different between the two groups. In the eleven-parameter discriminant analysis by APSP using single parameters, PFR, V75 (flow rate at 75% of forced vital capacity), and FEV1.0% were considered to be the effective parameters. In the seven-parameter discriminant analysis using the parameter groups, the group of all parameters and the %FVC and flow rate-related parameter group were considered to be the effective numerical alternatives to MEFV curves discriminating between healthy adults and asthmatic patients.</p>
キーワード asthma discriminant analysis flow-volume parameters
Amo Type Article
発行日 1986-08
出版物タイトル Acta Medica Okayama
40巻
4号
出版者 Okayama University Medical School
開始ページ 215
終了ページ 223
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 3766205
Web of Science KeyUT A1986D870500006
JaLCDOI 10.18926/AMO/31753
フルテキストURL fulltext.pdf
著者 Ogata, Masana| Fujii, Yasuhito| Meguro, Tadamichi| Kira, Shohei| Matsuda, Akira| Izushi, Fumio| Kimoto, Tetsuo| Takahara, Shigeo|
抄録 In an attempt to determine the level and heat stability of residual catalase in somatic cells of acatalasemic Japanese, skin fibroblasts from an acatalasemic subject were cultured, and the catalase activity of the cultured fibroblasts was compared with that of cultured normal fibroblasts. Catalase activity was determined using an oxygen electrode. The residual catalase activity in cultured acatalasemic fibroblasts was 10% of the normal. The heat stability at 55 degrees C of residual catalase in the acatalasemic fibroblasts was similar to that of normal fibroblasts.
キーワード tissue culture skin fibroblast actalasemia catalase
Amo Type Article
発行日 1987-10
出版物タイトル Acta Medica Okayama
41巻
5号
出版者 Okayama University Medical School
開始ページ 201
終了ページ 204
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
著作権者 Copyright© 1999 Okayama University Medical School
論文のバージョン publisher
査読 有り
PubMed ID 3687491
Web of Science KeyUT A1987K590100003
関連URL http://ousar.lib.okayama-u.ac.jp/metadata/5561
JaLCDOI 10.18926/AMO/31738
フルテキストURL fulltext.pdf
著者 Meguro, Tadamichi|
抄録 <p>Pregnant normal (N) and acatalasemic (A) mice treated with aminotriazole (AT) were exposed to metallic mercury. The mercury contents of the fetus and maternal organs were subsequently determined. The fetal and placental mercury contents were the highest in the AT-treated A mice (A-AT), and the contents decreased in the order of AT-treated N mice (N-AT), non-treated N mice (N-C) and non-treated A mice (A-C). Statistically significant differences in the fetal mercury levels were observed between N-C and A-C, A-C and N-AT, and N-AT and A-AT. The ratios of the mercury concentration in the fetus to that in the maternal blood decreased in the order of A-AT, N-AT, A-C and N-C. The differences in the ratio were significant between these groups. Similar results were obtained when the ratios of the maternal liver level to the maternal blood level or the ratios of the placental level to the maternal blood level were compared. The effect of AT on mercury uptake is remarkable in the fetus of both normal and acatalasemic mice exposed to metallic mercury.</p>
キーワード aminotriazole mercury uptake fetus acatalasemic mice metallic mercury
Amo Type Article
発行日 1987-12
出版物タイトル Acta Medica Okayama
41巻
6号
出版者 Okayama University Medical School
開始ページ 243
終了ページ 248
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 3439479
Web of Science KeyUT A1987L530300002
JaLCDOI 10.18926/AMO/31594
フルテキストURL fulltext.pdf
著者 Nishioka, Keiko| Meguro, Tadamichi| Okano, Mitsuhiro| Masuda, Yu| Saito, Chisato| Yasumitsu, Eiji|
抄録 <p>Fifteen patients with Japanese cedar pollenosis were examined for lower airway function. Flow-volume patterns obtained from flow-volume and volume-time curves during the pollen season (March) and outside of the pollen season (June) were evaluated. In a previous report we classified maximal expiratory flow-volume (MEFV) curves in five patterns from A to E. In the present study, the patterns did not vary between the two periods except in one patient. Eleven patients out of 15 showed type E patterns, in which the flow-volume curve was concave along its entire course. In most of the patients with severe or moderate symptoms of allergic rhinitis only during the pollen season, the curve shifted to the right, but the parameters of the curves did not increase significantly outside of season. These findings suggest that patients with Japanese cedar pollenosis suffer from continuous latent peripheral airway obstruction. Extremely slight changes in the flow rate were detected by comparing the curves obtained during the two periods.</p>
キーワード pulmonary function test pollenosis pollinosis maximal expiratory flow-volume curve flowvolume pattern
Amo Type Article
発行日 1993-06
出版物タイトル Acta Medica Okayama
47巻
3号
出版者 Okayama University Medical School
開始ページ 151
終了ページ 156
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 8379343
Web of Science KeyUT A1993LL12400003
JaLCDOI 10.18926/AMO/31071
フルテキストURL fulltext.pdf
著者 Meguro, Tadamichi| Tsubota, Nobutaka| Ogata, Masana|
抄録 <p>With the parameters of a flow-volume and a volume-time curve, the discriminant analysis of bronchial asthma is described. The subjects were classified into three groups (healthy adults, mild asthmatic patients and moderates ones). The difference of the mean vectors of the parameters of the three groups was made clear by the selection methods of the discriminant analysis between any two of the groups both with 6 parameters (%FVC, FEV1.0%, peak flow rate (PF), flow rate at 50% of FVC (V50), flow rate at 25% of FVC (V25), and V50/V25) and with 8 (6 parameters mentioned above and V75, V10). Forced expiratory volume in 1 second percent (FEV1.0%) or V50 was selected at the first step with 6 parameters, and V75 was selected at the first step with 8 parameters. Probabilities of misclassification with 8 parameters were lower than those with 6 ones and the probability of misclassification at the discriminant analysis between healthy adults and mild asthmatic patients with 8 parameters was 15.75% at the final step.</p>
キーワード discriminant analysis bronchial asthma flow-volume curve young male non-smokers
Amo Type Article
発行日 1978-10
出版物タイトル Acta Medica Okayama
32巻
5号
出版者 Okayama University Medical School
開始ページ 355
終了ページ 361
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 153096
NAID 120002313225
JaLCDOI 10.18926/AMO/30675
フルテキストURL fulltext.pdf
著者 Meguro, Tadamichi| Ogata, Masana|
抄録 <p>Volume-time (V-T) and flow-volume (F-V) curves were measured in all the subjects of nonsmoking young males (mean value 26.3 yrs.), healthy and asthmatic. Eleven parameters of pulmonary function tests, which were composed of two V-T, six F-V, and three mean time constants (MTC) parameters, were calculated from the curves. These were used in the discriminant analysis through all possible selection procedures (APSP) to make clear the importance of the F-V recognition. In using only one parameter, V75, which was one of the F-V parameters, showed the lowest probability of misclassification, 18.78%, and was the most useful parameter to discriminate the two groups. The probability of misclassification of the eleven parameters showed 15.46%, and that of the six F-V ones showed 17.45%. Though the probability of the six F-V ones was higher than that of the eleven ones, it was lower than that of the twoV-T or of the three MTC ones. Therefore the six F-V parameters including V75 was sufficient to discriminate the two groups of subjects. Thus it was made clear that the flow-volume recognition was important by the discriminant analysis.</p>
キーワード discriminant analysis volume-time and flow-volume curve the all possible selection produre (APSP) bronchial asthma probability of misclassification
Amo Type Article
発行日 1982-04
出版物タイトル Acta Medica Okayama
36巻
2号
出版者 Okayama University Medical School
開始ページ 133
終了ページ 139
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 7136850
Web of Science KeyUT A1982NM45300006
JaLCDOI 10.18926/AMO/30654
フルテキストURL fulltext.pdf
著者 Meguro, Tadamichi| Ogata, Masana|
抄録 <p>Volume-time (V-T) and flow-volume (F-V) curves were measured in all the subjects of nonsmoking young males (mean value 26.3 yrs. of age), healthy and asthmatics. Eleven parameters of pulmonary function tests composed of two V-T, six F-V, and three mean time constant (MTC) parameters, were calculated from the curves. These parameters were used in the two analyses through the all possible selection procedure (APSP) discriminating between healthy adults and mild asthmatics and also between healthy and moderate. Flow rate at 75% of FVC (V75) proved to be the most useful parameter and V50 the next best in both analyses. The probability of misclassification using all eleven parameters was 19.64% in the analysis of healthy adults and mild asthmatics, and 4.29% in the analysis of healthy adults and moderate asthmatics. There was a little difference in the parameters selected at every step. The discriminant analysis proved that the flow-volume patterns were different according to the severity of bronchial asthma. Thus flow-volume recognition was considered to be important in analyzing the severity of bronchial asthma.</p>
キーワード discriminant analysis the volume-time and flow-volume curve the all possible selection procedure (APSP) asthmatic severity and the probability of misclassification
Amo Type Article
発行日 1982-08
出版物タイトル Acta Medica Okayama
36巻
4号
出版者 Okayama University Medical School
開始ページ 299
終了ページ 306
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 7136859
Web of Science KeyUT A1982PE61100007
JaLCDOI 10.18926/AMO/30449
フルテキストURL fulltext.pdf
著者 Meguro, Tadamichi| Ishii, Kunihiko| Ogata, Masana|
抄録 <p>To clarify the relationship between the catalase activity in mouse organs and the amounts of metallic mercury exhaled, normal, homozygous hypocatalasemic and acatalasemic mice were injected with mercuric chloride. The cumulative amount of metallic mercury exhaled by mice was evidently expressed in the descending order of acatalasemic, hypocatalasemic, and normal mice. Statistically significant differences in the cumulative exhaled metallic mercury levels were observed between acatalasemic and hypocatalasemic mice, between normal and hypocatalasemic mice, and between acatalasemic and normal mice using the method of one way analysis of variance (ANOVA). A linear relationship was obtained through logarithm of catalase activity in the lungs or the blood, and logarithm of the cumulative amount of the exhaled mercury.</p>
キーワード catalase metallic mercury acatalasemic mice hypocatalasemic mice exhalation
Amo Type Article
発行日 1990-10
出版物タイトル Acta Medica Okayama
44巻
5号
出版者 Okayama University Medical School
開始ページ 251
終了ページ 256
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 2260496
Web of Science KeyUT A1990EG00700003
JaLCDOI 10.18926/AMO/30432
フルテキストURL fulltext.pdf
著者 Meguro, Tadamichi| Ogata, Masana|
抄録 <p>Pulmonary function tests were performed on 234 healthy non-smoking young subjects (189 males and 45 females free from respiratory and allergic symptoms). Maximal expiratory flow-volume (MEFV) curves were visually classified into five MEFV types: Type A, convex or straight flow changes; types B, C, and D, concave-convex-concave flow changes; and type E, sudden flow-fall and accompanying decreased flow rates at lower lung volumes. The reproducibility of MEFV patterns were shown by one way analysis of variance (ANOVA) of MEFV data obtained from 4 groups each consisting of 3-4 males and representing different MEFV types. Distribution of MEFV types was different between males and females; the rate of type A was higher in females than in males and those of types B and E were higher in males than in females. When analyzed in terms of three fractional flow rates, Fr-75, Fr-50, and Fr-25, these values could also be classified into 5 types similarly to the visual MEFV type analysis. It is concluded that MEFV type analysis is useful in assessing health conditions.</p>
キーワード maximal expiratory flow-volume type sex difference
Amo Type Article
発行日 1990-12
出版物タイトル Acta Medica Okayama
44巻
6号
出版者 Okayama University Medical School
開始ページ 293
終了ページ 300
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 2075828
Web of Science KeyUT A1990EP70700002