JaLCDOI 10.18926/AMO/31724
フルテキストURL fulltext.pdf
著者 Watanabe, Kazuhide| Matsuka, Naoyuki| Okazaki, Masatoshi| Hashimoto, Yasuhiko| Araki, Hiroaki| Gomita, Yutaka|
抄録 <p>The effects of immobilization stress on the pharmacokinetics of omeprazole were studied in rats. The immobilization stress for 30 or 60 min immediately after oral administration of the drug caused an increase in the time to reach the maximum concentration. However, such stress did not alter the area under the plasma concentration-time curve (AUC). When administered intravenously, the half-life during the elimination phase was significantly prolonged by 30 min of immobilization stress, but the AUC value remained unchanged. The intestinal propulsive activity was significantly decreased by immobilization stress. These findings suggest that immobilization stress reduces gastrointestinal motility. A resulting delay during the absorption phase of omeprazole occurs, although the degree of influence on overall pharmacokinetics is relatively insignificant.</p>
キーワード omeprazole pharmacokinetics stress immobilization
Amo Type Article
発行日 2002-02
出版物タイトル Acta Medica Okayama
56巻
1号
出版者 Okayama University Medical School
開始ページ 19
終了ページ 23
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 11873940
Web of Sience KeyUT 000174031300004
JaLCDOI 10.18926/AMO/31615
フルテキストURL fulltext.pdf
著者 Araki, Hiroaki| Kawasaki, Machiko| Matsuka, Naoyuki| Nakatsuma, Akira| Watanabe, Kazuhide| Futagami, Koujiro| Gomita, Yutaka|
抄録 <p>The effects of exposure to cigarette smoke on the pharmacokinetics and pharmacodynamics of zonisamide, an antiepileptic drug, were investigated in rats. Absorption of oral zonisamide was significantly inhibited by exposure to cigarette smoke. The Cmax, T1/2 and the area under the plasma concentration-time curve 0-24 values in the cigarette smoke exposure group were significantly lower than those in the control group. Although tonic extension (TE) induced by maximal electroshock was completely blocked by the administration of zonisamide in the control group, 50% of rats showed TE in the cigarette smoke exposure group. Exposure to cigarette smoke influences both the pharmacokinetics and antiepileptic effects of zonisamide. The effects of smoking on epileptic patients using zonisamide warrants further attention.</p>
キーワード cigarette smoking nicotine absorption convulsion zonisamide
Amo Type Article
発行日 1999-08
出版物タイトル Acta Medica Okayama
53巻
4号
出版者 Okayama University Medical School
開始ページ 185
終了ページ 188
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 10488405
Web of Science KeyUT 000082334300004
JaLCDOI 10.18926/AMO/30470
フルテキストURL fulltext.pdf
著者 Watanabe, Kazuhide| Matsuka, Naoyuki| Furuno, Katushi| Eto, Kohei| Kawasaki, Hiromu| Gomita, Yutaka|
抄録 <p>In order to evaluate a clinical use of omeprazole suspension, we examined the pharmacokinetics of omeprazole after oral administration in rats. Although the administration of omeprazole suspension buffered by NaHCO3 solution did not produce a significant increase in the area under the concentration-time curve (AUC) value compared with non-buffered group, the administration of NaHCO3 buffer immediately after dosing of omeprazole suspension buffered by NaHCO3 caused a significant increase in the AUC value. These results suggest that the NaHCO3 treatment following the administration of omeprazole buffered suspension effectively decreased the degradation of the compound by gastric acid. Therefore, the successive administration of NaHCO3 solution after the omeprazole dosing seems to be a simple and useful method for the administration to patients who cannot receive tablets.</p>
キーワード omeprazole suspension pharmacokinetics rats
Amo Type Article
発行日 1996-08
出版物タイトル Acta Medica Okayama
50巻
4号
出版者 Okayama University Medical School
開始ページ 219
終了ページ 222
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 8874584
Web of Science KeyUT A1996VE60800006